Evidence map›Paper›PMID 33320945›Full record

ArticleAge and ageing2021

Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study.

Sarah J Richardson, Daniel H J Davis, Blossom C M Stephan, Louise Robinson, Carol Brayne, Linda E Barnes, John-Paul Taylor, Stuart G Parker, Louise M Allan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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  17. Delirium: a modifiable risk factor for dementia.European geriatric medicine · 2026
    Review
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  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Sarah J RichardsonTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Daniel H J DavisMRC Unit for Lifelong Health and Ageing at UCL, London WC1E 7HB, UK.
Blossom C M StephanInstitute of Mental Health, Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham NG7 2TU, UK.
Louise RobinsonInstitute of Population Health Sciences, Faculty of Medical Sciences, Newcastle University, Biomedical Research Building, Newcastle upon Tyne NE4 5PL, UK.
Carol BrayneCambridge Public Health, Cambridge Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK.
Linda E BarnesCambridge Public Health, Cambridge Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK.
John-Paul TaylorTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.
Stuart G ParkerInstitute of Population Health Sciences, Faculty of Medical Sciences, Newcastle University, Biomedical Research Building, Newcastle upon Tyne NE4 5PL, UK.
Louise M AllanCollege of Medicine and Health, South Cloisters, University of Exeter, Exeter EX1 2LU, UK.
Newcastle University · GBUniversity of Cambridge · GBInstitute of Mental Health · GBMRC Unit for Lifelong Health and Ageing · GBUniversity of Exeter · GB

Funding

Medical Research Council G0601022Medical Research Council G9901400Wellcome Trust 107467/Z/15/Z
6 · The paper itself

Abstract

backgroundDelirium is common, distressing and associated with poor outcomes. Previous studies investigating the impact of delirium on cognitive outcomes have been limited by incomplete ascertainment of baseline cognition or lack of prospective delirium assessments. This study quantified the association between delirium and cognitive function over time by prospectively ascertaining delirium in a cohort aged ≥ 65 years in whom baseline cognition had previously been established.

methodsFor 12 months, we assessed participants from the Cognitive Function and Ageing Study II-Newcastle for delirium daily during hospital admissions. At 1-year, we assessed cognitive decline and dementia in those with and without delirium. We evaluated the effect of delirium (including its duration and number of episodes) on cognitive function over time, independently of baseline cognition and illness severity.

resultsEighty two of 205 participants recruited developed delirium in hospital (40%). One-year outcome data were available for 173 participants: 18 had a new dementia diagnosis, 38 had died. Delirium was associated with cognitive decline (-1.8 Mini-Mental State Examination points [95% CI -3.5 to -0.2]) and an increased risk of new dementia diagnosis at follow up (OR 8.8 [95% CI 1.9-41.4]). More than one episode and more days with delirium (>5 days) were associated with worse cognitive outcomes.

conclusionsDelirium increases risk of future cognitive decline and dementia, independent of illness severity and baseline cognition, with more episodes associated with worse cognitive outcomes. Given that delirium has been shown to be preventable in some cases, we propose that delirium is a potentially modifiable risk factor for dementia.

Indexed as

Cognitive DysfunctionDeliriumDementiaCognitionHumansProspective Studiescohort studydeliriumdementiaepidemiologyolder people

Identifiers

PMID33320945
PMCPMC8099011
OpenAlexW3090587907

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.