ArticlePloS one2020
Chronic kidney disease as a risk factor for peripheral nerve impairment in older adults: A longitudinal analysis of Health, Aging and Body Composition (Health ABC) study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- The Usefulness of Falls Efficacy Scale-International in Predicting Falls in Chronic Kidney Disease Patients.Journal of clinical medicine · 2026Article
- Article
- The Spectrum of Motor Disorders in Patients with Chronic Kidney Disease: Pathogenic Mechanisms, Clinical Manifestations, and Therapeutic Strategies.Journal of clinical medicine · 2026Review
- Neuropathic Pain, Polyneuropathy, and Quality of Life in Patients Receiving Dialysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Observational
- Frailty and peripheral neuropathy in hemodialysis patients: clinical and electrophysiological correlations.Renal failure · 2025Article
- Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes.BMC geriatrics · 2025Article
- Motor Coordination Disorders in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2025Article
- Quality matters: chronic kidney disease progression is associated with reduced muscle strength independently of changes in skeletal muscle mass: an observational study.Clinical kidney journal · 2025Article
- Association of HbA1c Variability with Vibrating Perception Threshold in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Analysis of the rate of force development reveals high neuromuscular fatigability in elderly patients with chronic kidney disease.Journal of cachexia, sarcopenia and muscle · 2023Article
- The Role of Mitochondrial and Redox Alterations in the Skeletal Myopathy Associated with Chronic Kidney Disease.Antioxidants & redox signaling · 2023Review
- Peripheral nerve morphology and intraneural blood flow in chronic kidney disease with and without diabetes.Muscle & nerve · 2022Article
- Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
introductionSensory and motor nerve deficits are prevalent in older adults and are associated with loss of functional independence. We hypothesize that chronic kidney disease predisposes to worsening sensorimotor nerve function over time. MATERIALS AND
methodsParticipants were from the Health, Aging and Body Composition Study (N = 1121) with longitudinal data between 2000-01 (initial visit) and 2007-08 (follow-up visit). Only participants with non-impaired nerve function at the initial visit were included. The predictor was presence of CKD (estimated GFR ≤ 60 ml/min/1.73m2) from the 1999-2000 visit. Peripheral nerve function outcomes at 7-year follow-up were 1) Motor: "new" impairments in motor parameters (nerve conduction velocity NCV < 40 m/s or peroneal compound motor action potential < 1 mv) at follow-up, and 2) Sensory: "new" impairment defined as insensitivity to standard 10-g monofilament or light 1.4-g monofilament at the great toe and "worsening" as a change from light to standard touch insensitivity over time. The association between CKD and "new" or "worsening" peripheral nerve impairment was studied using logistic regression.
resultsThe study population was 45.9% male, 34.3% Black and median age 75 y. CKD participants (15.6%) were older, more hypertensive, higher in BMI and had 2.37 (95% CI 1.30-4.34) fold higher adjusted odds of developing new motor nerve impairments in NCV. CKD was associated with a 2.02 (95% CI 1.01-4.03) fold higher odds of worsening monofilament insensitivity. CKD was not associated with development of new monofilament insensitivity.
conclusionsPre-existing CKD leads to new and worsening sensorimotor nerve impairments over a 7-year time period in community-dwelling older adults.
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