Evidence map›Paper›PMID 33320784›Full record

Observational studyAmerican journal of respiratory and critical care medicine2021

Kinetic Changes of Plasma Renin Concentrations Predict Acute Kidney Injury in Cardiac Surgery Patients.

Mira Küllmar, Khaschayar Saadat-Gilani, Raphael Weiss, Christina Massoth, Anas Lagan, Manuel Núñez Cortés, Joachim Gerss, Lakhmir S Chawla, Danilo Fliser, Melanie Meersch and 1 more

3 registry-linked trialsAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05824767 phase4completednot on this mapstarted 2023, after this paper: background citation

DPP3, Angiotensin II, and Renin Kinetics in Sepsis (DARK-Sepsis) Pilot: Serum Biomarkers to Predict Response to Angiotensin II vs. Standard-of-care Vasopressor Therapy in the Treatment of Septic Shock, a Randomized Controlled Pilot Trial

TypeinterventionalSponsorUniversity of New MexicoRan2023 to 2025Enrolled42ConditionsSeptic Shock, Vasodilatory ShockArmsAngiotensin II
NCT05898126 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Personalized Hemodynamic Management Based on Serum Renin Concentration on Acute Kidney Injury Progression in Patients With Shock: a Randomized Controlled Trial.

TypeinterventionalSponsorUniversità Vita-Salute San RaffaeleRan2025 to 2027Enrolled800ConditionsShockArmsRenin-guided hemodynamic management, Usual care
NCT06539234 recruitingnot on this mapstarted 2024, after this paper: background citation

Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II in Relation to Hemodynamic Response to Treatment With Angiotensin II.

TypeobservationalSponsorUniversity Medical Centre MariborRan2024 to 2026Enrolled80ConditionsShock, Vasoplegic Syndrome
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 73 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Observational
  8. Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025
    Article
  9. Review
  10. Vasoactive Agents in Burn Patients: Perspectives on Angiotensin-II.Journal of burn care & research : official publication of the American Burn Association · 2025
    Review
  11. Article
  12. Article
  13. New drugs for acute kidney injury.Journal of intensive medicine · 2025
    Review
  14. Article
  15. Vasopressor Therapy.Journal of clinical medicine · 2024
    Review
  16. Review
  17. Review
  18. Renin in critically ill patients.Annals of intensive care · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Mira KüllmarDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Khaschayar Saadat-GilaniDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Raphael WeissDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Christina MassothDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Anas LaganDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Manuel Núñez CortésDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Joachim GerssInstitute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
Lakhmir S ChawlaVeterans Affairs Medical Center, San Diego, California; and.
Danilo FliserDepartment of Internal Medicine 4, Nephrology and Hypertension, Saarland University Hospital, Homburg/Saar, Germany.
Melanie MeerschDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
Alexander ZarbockDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Muenster, Muenster, Germany.
University Hospital Münster · DESaarland University · DESan Francisco VA Medical Center · USUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Kidney InjuryAgedCardiac Surgical ProceduresCardiopulmonary BypassFemaleHumansHypotensionLength of StayMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsProspective StudiesReninRisk FactorsROC CurveReninacute kidney injurycardiac surgeryrenin

Identifiers

PMID33320784
OpenAlexW3113310398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.