ArticleAnalytical chemistry2021
Concurrent Vibrational Circular Dichroism Measurements with Infrared Spectroscopic Imaging.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Transfer-Matrix Framework for Modeling Mid-Infrared Vibrational Circular Dichroism Spectra.Analytical chemistry · 2026Article
- Time-Domain Quantum Cascade Laser-Based Vibrational Circular Dichroism Spectroscopy with Linear Dichroism Monitoring.Analytical chemistry · 2025Article
- Rapid Vibrational Circular Dichroism Spectroscopy via Synchronized Photoelastic Modulator-Quantum Cascade Laser Integration.ACS measurement science au · 2025Article
- External Cavity Quantum Cascade Laser Vibrational Circular Dichroism Spectroscopy for Fast and Sensitive Analysis of Proteins at Low Concentrations.Analytical chemistry · 2024Article
- Time-Resolved Mid-Infrared Photothermal Microscopy for Imaging Water-Embedded Axon Bundles.Analytical chemistry · 2023Article
- Single-detector double-beam modulation for high-sensitivity infrared spectroscopy.Scientific reports · 2023Article
- Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging.Nature communications · 2023Article
- Digital Histopathology by Infrared Spectroscopic Imaging.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023Review
- Cell Phase Identification in a Three-Dimensional Engineered Tumor Model by Infrared Spectroscopic Imaging.Analytical chemistry · 2023Article
- Resolution Limit in Infrared Chemical Imaging.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- On the Limit of Detection in Infrared Spectroscopic Imaging.Applied spectroscopy · 2022Article
- Label-Free Infrared Spectroscopic Imaging Reveals Heterogeneity of β-Sheet Aggregates in Alzheimer's Disease.The journal of physical chemistry letters · 2021Article
- Design Considerations for Discrete Frequency Infrared Microscopy Systems.Applied spectroscopy · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vibrational circular dichroism (VCD) spectroscopy has emerged as a powerful platform to quantify chirality, a vital biological property that performs a pivotal role in the metabolism of life organisms. With a photoelastic modulator (PEM) integrated into an infrared spectrometer, the differential response of a sample to the direction of circularly polarized light can be used to infer conformation handedness. However, these optical components inherently exhibit chromatic behavior and are typically optimized at discrete spectral frequencies. Advancements of discrete frequency infrared (DFIR) spectroscopic microscopes in spectral image quality and data throughput are promising for use toward analytical VCD measurements. Utilizing the PEM advantages incorporated into a custom-built QCL microscope, we demonstrate a point scanning VCD instrument capable of acquiring spectra rapidly across all fingerprint region wavelengths in transmission configuration. Moreover, for the first time, we also demonstrate the VCD imaging performance of our instrument for site-specific chirality mapping of biological tissue samples. This study offers some insight into future possibilities of examining small, localized changes in tissue that have major implications for systemic diseases and their progression, while also laying the groundwork for additional modeling and validation in advancing the capability of VCD spectroscopy and imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.