ArticleBrain and behavior2021
Intrasubject functional connectivity related to self-generated thoughts.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relative Accuracy of Different Methods for Measuring Mind Wandering Subtypes: A Systematic Review.Brain and behavior · 2025Pooled it
- Thought contents during rest account for functional connectivity-behavior associations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Quantification of brain functional connectivity deviations in individuals: A scoping review of functional MRI studies.NeuroImage. Clinical · 2025Article
- Functional brain connectivity changes associated with day-to-day fluctuations in affective states.Cognitive, affective & behavioral neuroscience · 2024Article
- Intrasubject functional connectivity related to self-generated thoughts.Brain and behavior · 2021Article
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Authors and funding
3 authors.
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Abstract
introductionIn psychiatric research, functional connectivity (FC) derived from resting-state functional MRI (rsfMRI) is often used to investigate brain abnormalities in psychiatric disorders. This approach assumes implicitly that FC can recover reliable maps of the functional architecture of the brain and that these profiles of connectivity reflect trait differences underlying pathology. However, evidence of FC related to self-generated thoughts (mind-wandering) stands in contrast with these assumptions, as FC may reflect thought patterns rather than functional architecture.
methodsMulti-factor analysis (MFA) was used to investigate the reported content of self-generated thoughts during high-field (7T) rsfMRI in a repeated sample of 22 healthy individuals. To investigate the relationship between these experiences and FC, individual scores for each of these dimensions were compared with whole-brain connectivity using the network-based statistic (NBS) method.
resultsThis analysis revealed three dimensions of thought content: self-referential thought, negative thoughts about one's surroundings, and thoughts in the form of imagery. A network of connections within the sensorimotor cortices negatively correlated with self-generated thoughts concerning the self was observed (p = .0081, .0486 FDR).
conclusionThese results suggest a potentially confounding relationship between self-generated thoughts and FC, and contribute to the body of research concerning the functional representation of mind-wandering.
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