ArticleAngewandte Chemie (International ed. in English)2021
Structural Characterization of Two CO Molecules Bound to the Nitrogenase Active Site.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 70 citations in OpenAlex.
- Molybdenum doping enhances backbonding at neighboring iron centers in iron-sulfur clusters.Chem · 2026Article
- Recasting Nitrogenase's Carbide Role as a Beating Heart of Steel: A Joint Inorganic and Organic Perspective for μInorganic chemistry · 2026Article
- Single-Step Insertion of Organic Sulfur Into a FeAngewandte Chemie (International ed. in English) · 2025Article
- Belt-Sulfur Mobilization as a Crucial Mechanistic Feature Shared between the Vanadium and Molybdenum Nitrogenases.Chem catalysis · 2025Article
- Chemical and Electrochemical Investigation of the Oxidation of a Highly Reduced FeInorganic chemistry · 2025Article
- The nitrogenase mechanism: new roles for the dangler?Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Review
- Investigating the Molybdenum Nitrogenase Mechanistic Cycle Using Spectroelectrochemistry.Journal of the American Chemical Society · 2025Article
- Structural evolution of nitrogenase states under alkaline turnover.Nature communications · 2024Article
- Bridging Carbonyl and Carbyne Complexes of Weak-Field Iron: Electronic Structure and Iron-Carbon Bonding.Journal of the American Chemical Society · 2024Article
- Reaction Mechanism for CO Reduction by Mo-Nitrogenase Studied by QM/MM.Inorganic chemistry · 2024Article
- Anaerobic cryoEM protocols for air-sensitive nitrogenase proteins.Nature protocols · 2024Review
- Highly Activated Terminal Carbon Monoxide Ligand in an Iron-Sulfur Cluster Model of FeMco with Intermediate Local Spin State at Fe.Journal of the American Chemical Society · 2024Article
- On the Shoulders of Giants-Reaching for Nitrogenase.Molecules (Basel, Switzerland) · 2023Review
- Nitrogenase beyond the Resting State: A Structural Perspective.Molecules (Basel, Switzerland) · 2023Review
- An Iron-Sulfur Cluster with a Highly Pyramidalized Three-Coordinate Iron Center and a Negligible Affinity for Dinitrogen.Journal of the American Chemical Society · 2023Article
- Highly Reduced Ruthenium Carbide Carbonyl Clusters: Synthesis, Molecular Structure, Reactivity, Electrochemistry, and Computational Investigation of [RuInorganic chemistry · 2023Article
- Electrochemical experiments define potentials associated with binding of substrates and inhibitors to nitrogenase MoFe protein.Faraday discussions · 2023Article
- Enzymatic Fischer-Tropsch-Type Reactions.Chemical reviews · 2023Review
- Sulfur-Ligated [2Fe-2C] Clusters as Synthetic Model Systems for Nitrogenase.Inorganic chemistry · 2023Article
- The HD Reaction of Nitrogenase: a Detailed Mechanism.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
As an approach towards unraveling the nitrogenase mechanism, we have studied the binding of CO to the active-site FeMo-cofactor. CO is not only an inhibitor of nitrogenase, but it is also a substrate, undergoing reduction to hydrocarbons (Fischer-Tropsch-type chemistry). The C-C bond forming capabilities of nitrogenase suggest that multiple CO or CO-derived ligands bind to the active site. Herein, we report a crystal structure with two CO ligands coordinated to the FeMo-cofactor of the molybdenum nitrogenase at 1.33 Å resolution. In addition to the previously observed bridging CO ligand between Fe2 and Fe6 of the FeMo-cofactor, a new ligand binding mode is revealed through a second CO ligand coordinated terminally to Fe6. While the relevance of this state to nitrogenase-catalyzed reactions remains to be established, it highlights the privileged roles for Fe2 and Fe6 in ligand binding, with multiple coordination modes available depending on the ligand and reaction conditions.
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