ArticleClinical transplantation2021
Karnofsky performance status predicts outcomes in candidates for simultaneous liver-kidney transplant.
Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- AASLD AST Practice Guideline on adult liver transplantation: Candidate evaluation.Hepatology (Baltimore, Md.) · 2026Guideline
- Comparison of Survival Prognostic Tools in Terminal-Stage Tumor Patients: A Multicenter Prospective Cohort Study.Cancer medicine · 2026Article
- Efficacy of calcium sulfate particles combined with allogeneic bone grafting on bone defects after surgery for benign bone tumors of the extremities.American journal of translational research · 2026Article
- Outcomes of Liver Transplantation in Patients With Severe Obesity: The Impact of Performance Status.Transplantation direct · 2025Article
- Reduced Functional Status among Kidney Transplant Recipients over Time and Associated Risks Post-Transplant.Clinical transplantation · 2025Article
- Longitudinal Assessment of Performance Status in US Liver Transplantation: National Trends and Survival Implications.Transplantation direct · 2025Article
- Advancements in nutritional diagnosis and support strategies during the perioperative period for patients with liver cancer.World journal of gastrointestinal surgery · 2024Review
- Prognostic impact of sodium fluorescein-guided microsurgery on cognitive function, neuropeptide dynamics, and short-term outcomes in brain glioma patients.American journal of cancer research · 2024Article
- Curettage of lesion combined with reconstruction of intramedullary nail and bone cement for the treatment of subtrochanteric metastatic tumors of the femur.American journal of cancer research · 2024Article
- Percutaneous pedicle screw fixation combined with percutaneous vertebroplasty for the treatment of thoracic and lumbar metastatic tumors.Journal of clinical and translational research · 2023Article
- Frailty as a predictor of poor outcomes among patients awaiting liver transplant: a systematic review and meta-analysis.Gastroenterology and hepatology from bed to bench · 2023Review
- Frailty and solid-organ transplant candidates: a scoping review.BMC geriatrics · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Karnofsky performance status (KPS), a measure of physical frailty, predicts pre-transplant and post-transplant outcomes in liver transplantation, but has not been assessed in simultaneous liver-kidney transplantation (SLKT). We examined the association between KPS and outcomes in SLKT waitlist registrants and recipients (2005-2018) in the UNOS database. KPS was categorized into A (able to work), B (able to provide self-care), and C (unable to provide self-care). Cox regression and competing risk analysis were used to assess the association between KPS groups and outcomes. A total of 10,785 patients were waitlisted (KPS: 19% A, 46% B, 35% C), and 5,516 underwent SLKT (12% A, 36% B, 52% C). One-year waitlist mortality was 17%, 22%, and 32% for KPS A, B, and C, respectively. In adjusted competing risk regression, KPS C was associated with increased waitlist mortality (SHR 1.15, 95%CI 1.04-1.28). One-year post-transplant survival was 92%, 91%, and 87% for KPS A, B, and C, respectively. In adjusted Cox regression, KPS C was associated with increased post-transplant mortality (HR 1.32, 95%CI 1.08-1.61). It was also associated with increased liver and kidney graft losses and with hospital length of stay. Frailty, as assessed by KPS, is associated with poor outcomes in SLKT pre- and post-transplant.
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