ArticleeLife2020
The tricuspid valve also maladapts as shown in sheep with biventricular heart failure.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed.
- Sex-Specific Remodeling Phenotypes of the Tricuspid Valve Leaflets in an Ovine Model of Functional Tricuspid Regurgitation.bioRxiv : the preprint server for biology · 2026Article
- The Tricuspid Valve Maladapts in a Pulmonary Hypertension Rat Model.bioRxiv : the preprint server for biology · 2026Article
- Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- The In-Situ Mechanics of the Tricuspid Valve: Strain Heterogeneity and Anisotropy via 3D Digital Image Correlation.Experimental mechanics · 2026Article
- Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- Tricuspid valve leaflet remodeling in sheep with biventricular heart failure: A comparison between leaflets.Acta biomaterialia · 2025Article
- Single-Cell Transcriptomics Identified Fibrosis-Activated Valve Interstitial Cells Involved in Functional Tricuspid Regurgitation.JACC. Asia · 2025Article
- Single-Cell Revelations in Tricuspid Valve Remodeling: A New Chapter in Functional Tricuspid Regurgitation.JACC. Asia · 2025Article
- Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions.Journal of the mechanical behavior of biomedical materials · 2025Article
- FEBio FINESSE: An Open-Source Finite Element Simulation Approach to Estimate In Vivo Heart Valve Strains Using Shape Enforcement.Annals of biomedical engineering · 2025Article
- How well do 3D-printed tissue mimics represent the complex mechanics of biological soft tissues? An example study with Stratasys' cardiovascular TissueMatrix materials.Journal of biomedical materials research. Part A · 2025Article
- Computational analysis of heart valve growth and remodeling after the Ross procedure.Biomechanics and modeling in mechanobiology · 2024Article
- Leaflet remodeling reduces tricuspid valve function in a computational model.Journal of the mechanical behavior of biomedical materials · 2024Article
- Atrial secondary tricuspid regurgitation: pathophysiology, definition, diagnosis, and treatment.European heart journal · 2024Article
- Impact of tricuspid annuloplasty device shape and size on valve mechanics-a computational study.JTCVS open · 2024Article
- Untangling the mechanisms of pulmonary arterial hypertension-induced right ventricular stiffening in a large animal model.Acta biomaterialia · 2023Article
- An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve leaflets.Journal of biomechanics · 2023Article
- The effects of leaflet material properties on the simulated function of regurgitant mitral valves.Journal of the mechanical behavior of biomedical materials · 2023Article
- Valvular complex and tissue remodelling in ovine functional tricuspid regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve-extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients rendering the valve at least partially culpable for its dysfunction. As a first step in testing this hypothesis, we set out to demonstrate that the tricuspid valve maladapts in disease. To this end, we induced biventricular heart failure in sheep that developed tricuspid valve leakage. In the anterior leaflets of those animals, we investigated maladaptation on multiple scales. We demonstrated alterations on the protein and cell-level, leading to tissue growth, thickening, and stiffening. These data provide a new perspective on a poorly understood, yet highly prevalent disease. Our findings may motivate novel therapy options for many currently untreated patients with leaky tricuspid valves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.