Evidence map›Paper›PMID 33320089›Full record

ArticleeLife2020

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones.

Shehryar Ahmad, Kara K Tsang, Kartik Sachar, Dennis Quentin, Tahmid M Tashin, Nathan P Bullen, Stefan Raunser, Andrew G McArthur, Gerd Prehna, John C Whitney

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  13. Structural and functional insights into Pseudomonas aeruginosa's secretion systems 1-6: regulation, role in microbial keratitis and drug targets.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  14. Tldi1 deficiency mediates Tlde1 self-toxic effect to regulate the adaptability ofFrontiers in cellular and infection microbiology · 2026
    Article
  15. Article
  16. A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system-exported toxins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Shehryar AhmadMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.ORCID 0000-0002-2747-5212
Kara K Tsang *Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.ORCID 0000-0001-7742-8855
Kartik Sachar *Department of Microbiology, University of Manitoba, Winnipeg, Canada.ORCID 0000-0003-4077-1734
Dennis QuentinDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID 0000-0003-3825-7066
Tahmid M TashinMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Nathan P BullenMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Stefan RaunserDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID 0000-0001-9373-3016
Andrew G McArthurMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.
Gerd PrehnaDepartment of Microbiology, University of Manitoba, Winnipeg, Canada.ORCID 0000-0001-5539-7533
John C WhitneyMichael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Canada.ORCID 0000-0002-4517-8836
McMaster University · CADiscovery Centre · CAMax Planck Institute of Molecular Physiology · DEUniversity of Manitoba · CA

Funding

Canadian Foundation for Innovation 34531Canadian Foundation for Innovation 37841CIHR PJT-156129CIHR PJT156214Natural Sciences and Engineering Research Council of Canada RGPIN-2017-05350Natural Sciences and Engineering Research Council of Canada RGPIN-2018-04968
6 · The paper itself

Abstract

Type VI secretion systems (T6SSs) deliver antibacterial effector proteins between neighboring bacteria. Many effectors harbor N-terminal

Indexed as

Escherichia coliMembrane ProteinsMolecular ChaperonesProtein ConformationProtein DomainsProtein TransportPseudomonas aeruginosaSalmonella typhimuriumType VI Secretion SystemsMembrane ProteinsMolecular ChaperonesType VI Secretion SystemsGram-negative bacteriainfectious diseaseinterbacterial competitionmicrobiologymolecular chaperonesprotein transporttype VI secretion systemx-ray crystallography

Identifiers

PMID33320089
PMCPMC7773334
OpenAlexW3112773133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.