ArticleeLife2020
Cold-induced hyperphagia requires AgRP neuron activation in mice.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Acute Heat and Cold Exposures at Rest or during Exercise on Subsequent Energy Intake: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Article
- Mice use predictive environmental cues to adapt predatory behavior in hunting tasks of variable difficulty.bioRxiv : the preprint server for biology · 2026Article
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Therapeutic effects of bee venom on high fat diet induced obesity and behavioral changes.Biologia futura · 2026Article
- Parabrachial neurons orchestrate cold-induced homeostatic responses.Nature metabolism · 2026Article
- AgRP neuron activity predicts and tracks the glycemic response to oral glucose.Molecular metabolism · 2026Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.Nature metabolism · 2026Article
- A Preoptic Neuronal Population Regulates Energy Expenditure and Balance.bioRxiv : the preprint server for biology · 2026Article
- AgRP Neuron Activity Predicts and Tracks the Glycemic Response to Oral Glucose.bioRxiv : the preprint server for biology · 2026Article
- Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.Communications biology · 2026Article
- Gut-to-brain signaling restricts dietary protein intake during recovery from catabolic states.Cell · 2025Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- ParabrachialiScience · 2025Article
- AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes.The Journal of clinical investigation · 2025Article
- Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem.Neuroscience bulletin · 2025Review
- A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy.Nature methods · 2025Article
- Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss.Metabolism: clinical and experimental · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
To maintain energy homeostasis during cold exposure, the increased energy demands of thermogenesis must be counterbalanced by increased energy intake. To investigate the neurobiological mechanisms underlying this cold-induced hyperphagia, we asked whether agouti-related peptide (AgRP) neurons are activated when animals are placed in a cold environment and, if so, whether this response is required for the associated hyperphagia. We report that AgRP neuron activation occurs rapidly upon acute cold exposure, as do increases of both energy expenditure and energy intake, suggesting the mere perception of cold is sufficient to engage each of these responses. We further report that silencing of AgRP neurons selectively blocks the effect of cold exposure to increase food intake but has no effect on energy expenditure. Together, these findings establish a physiologically important role for AgRP neurons in the hyperphagic response to cold exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.