Evidence map›Paper›PMID 33319987›Full record

ArticleACS chemical neuroscience2021

Characterization of Kinetic Isotope Effects and Label Loss in Deuterium-Based Isotopic Labeling Studies.

Robin A de Graaf, Monique A Thomas, Kevin L Behar, Henk M De Feyter

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Human Brain Deuterium Metabolic Imaging at 7 T: Impact of Different [6,6'-Journal of magnetic resonance imaging : JMRI · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. [6,6'-NMR in biomedicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robin A de GraafDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, P.O. Box 208043, New Haven, Connecticut 06520-8043, United States.
Monique A ThomasDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, P.O. Box 208043, New Haven, Connecticut 06520-8043, United States.
Kevin L BeharDepartment of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, P.O. Box 208043, New Haven, Connecticut 06520-8043, United States.
Henk M De FeyterDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, P.O. Box 208043, New Haven, Connecticut 06520-8043, United States.ORCID 0000-0001-6111-0316
Yale University · US

Funding

Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
Ex Vivo Assay for In Situ Brain-Wide Mapping of Glutamate/GABA MetabolismR01MH095104 · NIMH · YALE UNIVERSITY · PI BEHAR, KEVIN L, DE GRAAF, ROBIN A · 2011 to 2014
$2.0M
NIBIB NIH HHS R01 EB025840NIMH NIH HHS R01 MH095104
6 · The paper itself

Abstract

Deuterium metabolic imaging (DMI) is a novel, 3D, magnetic resonance (MR)-based method to map metabolism of deuterated substrates

Indexed as

Glutamic AcidGlutamineAnimalsCarbon IsotopesDeuteriumIsotope LabelingKineticsMagnetic Resonance SpectroscopyRatsCarbon IsotopesDeuteriumGlutamic AcidGlutamineacetateDeuteriumglucosekinetic isotope effectlabel loss

Identifiers

PMID33319987
PMCPMC9890388
OpenAlexW3112679104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.