ArticleScientific reports2020
The impact of fixed orthodontic appliances on oral microbiome dynamics in Japanese patients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Orthodontic treatment and oral microbiota changes: a systematic review of oral dysbiosis revealed by 16S rRNA gene analysis.The Angle orthodontist · 2025Pooled it
- Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a systematic review.European journal of orthodontics · 2023Pooled it
- Comparison of Clinical Effects of Essential Oil-Containing Mouthwash and Chlorhexidine Mouth Wash in Patients Undergoing Fixed Orthodontic Treatment - Three-Month Follow-up Randomized-Controlled Trial.Clinical and experimental dental research · 2026Trial
- Population-based characterisation of child and adolescent oral bacterial microbiomes.Microbiome · 2026Article
- Cuttlefish Ink-Derived Melanin Nanoparticles Enabling NIR-Responsive Electrospun Nanofibrous Mats for On-Demand Selective Antibacterial Disinfection of Orthodontic Braces.ACS applied materials & interfaces · 2026Article
- Supragingival dental biofilm microbiomes of tobacco heating system smokers, cigarette smokers and non-smokers.Clinical oral investigations · 2026Article
- Bacterial contamination and diversity of dental unit waterlines across dental specialties, outlets and distinct times: heterotrophic bacteria counting and sequencing analysis.Journal of oral microbiology · 2026Article
- Associations Between Halitosis and Craniofacial Morphology, Salivary Biochemical Parameters, and Mouth Breathing in Adult Patients with Malocclusion: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Integrative insights into the oral microbiome's role in systemic diseases: novel therapeutic strategies and future directions.Antonie van Leeuwenhoek · 2025Review
- Retrospective Assessment of Palatal Biofilm and Mucosal Inflammation Under Orthodontic Appliances in Young Adults (2022-2025): A Single-Center Cohort with Microbiologic Sub-Sampling.Dentistry journal · 2025Article
- Comparison of Long-Term Oral Bacterial Flora Before and After Orthognathic Surgery in Surgical Orthodontic Treatment.Dentistry journal · 2025Article
- Bacterial Colonization of Orthodontic Devices (Molar Bands, Nance Buttons, and Acrylic Plates) and Its Impact on the Marginal Periodontium and Palatal Fibromucosa in Teenagers: A Cross-Sectional Clinical-Microbiological Study.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Oral Microbiome Analysis and Caries Risk Classification Using the Caries Management by Risk Assessment System in Pre-Orthodontic Patients.Journal of clinical medicine · 2025Article
- Article
- DMAHDM@MPC nanoparticles in orthodontic adhesive inhibit cariogenic bacteria and sugar metabolism to prevent enamel demineralization.Materials today. Bio · 2025Article
- Comparison of Oral Microbial Profile Among Patients Undergoing Clear Aligner and Fixed Orthodontic Therapies for the Treatment of Malocclusions: An Updated Review.Dentistry journal · 2025Review
- The Impact of Orthodontic Adhesives on the Subgingival Microbiota During Early Fixed Appliance Therapy: A Pilot Study.Medicina (Kaunas, Lithuania) · 2025Article
- Influence of orthodontic appliances and nitrate on the oral microbiota.Applied microbiology and biotechnology · 2025Article
- Investigating the establishment of the rumen and oral bacterial communities in beef cattle and assessing the applicability of using the oral bacterial community composition as a proxy for rumen bacterial community structure in cattle.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fixed orthodontic appliances are common and effective tools to treat malocclusion. Adverse effects of these appliances, such as dental caries and periodontitis, may be associated with alteration of the microbiome. This study investigated the impact of these appliances on the dynamics of the oral microbiome. Seventy-one patients were selected. Supragingival plaque samples were collected before placement (T0) and six months after placement (T1). Saliva samples were collected at T0 and T1, and then when appliance removal (T2). Microbial DNA was analyzed by 16S rRNA meta-sequencing. The diversity analysis indicated dynamic changes in the structure of the oral microbiome. Taxonomic analysis at phylum level showed a significant increase in Bacteroidetes and Saccharibacteria (formally TM7) and decrease in Proteobacteria and Actinobacteria over time, in both plaque and saliva. Genus level analysis of relative abundance indicated a significant increase in anaerobic and facultative anaerobes in both plaque and saliva. Fixed orthodontic appliances induced measurable changes in the oral microbiome. This was characterized by an increase in relative abundance of obligate anaerobes, including periodontal pathogens. It can be concluded that this dysbiosis induced by fixed orthodontic appliances is likely to represent a transitional stage in the shift in microbiome from healthy to periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.