ArticleScientific reports2020
K
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In one paragraph
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Role for TREK-1 as a polymodal sensor and regulator of cell activity.Channels (Austin, Tex.) · 2026Review
- KPharmaceuticals (Basel, Switzerland) · 2026Review
- Advances in research on hyperoxia-induced acute lung injury: from pathogenesis to therapy.Frontiers in cell and developmental biology · 2026Review
- Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Pharmacological activation of BK channels protects against LPS-induced pneumonia.Scientific reports · 2025Article
- Pro-Reparative Effects of KvLQT1 Potassium Channel Activation in a Mouse Model of Acute Lung Injury Induced by Bleomycin.International journal of molecular sciences · 2025Article
- Mechanisms of impaired alveolar fluid clearance.Anatomical record (Hoboken, N.J. : 2007) · 2025Review
- Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias.Nature communications · 2024Article
- Evaluation of interleukin-1 and interleukin-6 receptor antagonists in a murine model of acute lung injury.Experimental physiology · 2024Article
- Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review.Critical care (London, England) · 2024Review
- Function of KvLQT1 potassium channels in a mouse model of bleomycin-induced acute lung injury.Frontiers in physiology · 2024Article
- Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.Biomedicines · 2023Article
- Activation of TREK-1 (American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Emerging roles of mechanosensitive ion channels in acute lung injury/acute respiratory distress syndrome.Respiratory research · 2022Review
- Salidroside attenuates HALI via IL-17A-mediated ferroptosis of alveolar epithelial cells by regulating Act1-TRAF6-p38 MAPK pathway.Cell communication and signaling : CCS · 2022Article
- Mechanism of Adipose-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miR-21-5p in Hyperoxia-Induced Lung Injury.Stem cell reviews and reports · 2022Article
- Negative Influence by the Force: Mechanically Induced Hyperpolarization via KInternational journal of molecular sciences · 2021Review
- Structural Insights into the Mechanisms and Pharmacology of KJournal of molecular biology · 2021Review
- Bepridil, a class IV antiarrhythmic agent, can block the TREK-1 potassium channel.Annals of translational medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Tatiana ZyrianovaDepartment of Pediatrics, University of California Los Angeles, 10833 Le Conte Ave, MDCC 12-475, Los Angeles, CA, 90095, USA.
Benjamin LopezDepartment of Pediatrics, University of California Los Angeles, 10833 Le Conte Ave, MDCC 12-475, Los Angeles, CA, 90095, USA.
Riccardo OlceseDepartment of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, USA.
John BelperioDepartment of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Christopher M WatersDepartment of Physiology, University of Kentucky, Lexington, KY, USA.
Leanne WongDepartment of Pediatrics, University of California Los Angeles, 10833 Le Conte Ave, MDCC 12-475, Los Angeles, CA, 90095, USA.
Victoria NguyenDepartment of Pediatrics, University of California Los Angeles, 10833 Le Conte Ave, MDCC 12-475, Los Angeles, CA, 90095, USA.
Sriharsha TalapaneniDepartment of Pediatrics, University of California Los Angeles, 10833 Le Conte Ave, MDCC 12-475, Los Angeles, CA, 90095, USA.
Andreas SchwingshacklDepartment of Pediatrics, University of California Los Angeles, 10833 Le Conte Ave, MDCC 12-475, Los Angeles, CA, 90095, USA. aschwingshackl@gmail.com.
University of California, Los Angeles · USUniversity of Kentucky · US
Funding
Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung InjuryR01HL146821 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHWINGSHACKL, ANDREAS · 2020 to 2024
$2.8MThe Late L-type Ca Current as the Target for a New Class of AntiarrhythmicsR01HL134346 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2017 to 2020
$2.3MBiophysical Mechanisms of Hyperoxia-Induced Lung InjuryR01HL151419 · NHLBI · UNIVERSITY OF KENTUCKY · PI WATERS, CHRISTOPHER M · 2020 to 2023
$2.1MASK1 and Ventilator-Induced Lung InjuryR01HL131526 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATERS, CHRISTOPHER M · 2017 to 2020
$1.7MThe Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.K08HL118118 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SCHWINGSHACKL, ANDREAS · 2014 to 2018
$792kNHLBI NIH HHS K08 HL118118NHLBI NIH HHS R01 HL131526NHLBI NIH HHS R01 HL134346NHLBI NIH HHS R01 HL146821NHLBI NIH HHS R01 HL151419NIH HHS HL118118-3 (AS)NIH HHS HL131526 (CMW)NIH HHS HL134346 (RO)
Abstract
No targeted therapies exist to counteract Hyperoxia (HO)-induced Acute Lung Injury (HALI). We previously found that HO downregulates alveolar K
Indexed as
Ion Channel GatingAcute Lung InjuryAlveolar Epithelial CellsAnimalsBronchoalveolar Lavage FluidCalciumCell LineCytokinesHyperoxiaInflammation MediatorsIntracellular SpaceMembrane PotentialsMice, Inbred C57BLPotassium Channels, Tandem Pore DomainProtective AgentsTetrahydronaphthalenes(5,6,7,8-tetrahydronaphthalen-1-yl)-(2-(1H-tetrazol-5-yl)phenyl)amineCalciumCytokinesInflammation Mediatorspotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainProtective AgentsTetrahydronaphthalenesTetrazoles
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.