ArticleNPJ schizophrenia2020
General psychopathology links burden of recent life events and psychotic symptoms in a network approach.
Article in NPJ schizophrenia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- A network approach exploring the effects of cognitive remediation on cognition, symptoms, and functioning in early psychosis.Psychological medicine · 2025Trial
- Early-Age onset of psychotic spectrum symptoms is highly prevalent and associated with greater illness severity in schizophrenia spectrum disorders that develop later in life.Social psychiatry and psychiatric epidemiology · 2026Observational
- Stressful life events and their association with symptom severity and functioning in first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Self-focused rumination links stressful events to depressive and anxiety symptoms in older adults with depressive symptoms: path and network analyses.Scientific reports · 2026Article
- Life events and their subjective appraisal by children and adolescents in clinical high-risk states of psychosis: a cross-sectional comparison with inpatients with non-psychotic disorders and community subjects.European child & adolescent psychiatry · 2026Article
- Unraveling the complex relationships between anxiety, depression, and quality of life in schizophrenia: a network analysis study.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between the Korea-Polyenvironmental Risk Score and Clinical Outcomes in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis.Biological psychiatry global open science · 2025Article
- An Introduction to the Human Connectome Project for Early Psychosis.Schizophrenia bulletin · 2025Article
- A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology.Schizophrenia bulletin · 2025Article
- Exploring the Working Mechanisms between Anxiety, Mental Imagery, and Auditory Verbal Hallucinations: A Longitudinal Study.Schizophrenia bulletin open · 2025Article
- The impact of life events on NSSI among left-behind college students: the mediating role of PLEs and the moderating role of social support.Frontiers in psychology · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
- Competence-Based Trainings for Psychological Treatments - A Transtheoretical Perspective.Clinical psychology in Europe · 2024Article
- Network Structure of Childhood Trauma, Bodily Disturbances, and Schizotypy in Schizophrenia and Nonclinical Controls.Schizophrenia bulletin open · 2024Article
- Developmental Trajectories of Internalizing and Externalizing Symptoms in Youth and Associated Gender Differences: A Directed Network Perspective.Research on child and adolescent psychopathology · 2023Article
- Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial.Translational psychiatry · 2023Article
- On the interplay of borderline personality features, childhood trauma severity, attachment types, and social support.Borderline personality disorder and emotion dysregulation · 2022Article
- Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?Translational psychiatry · 2022Review
- Parenting and psychosis: An experience sampling methodology study investigating the inter-relationship between stress from parenting and positive psychotic symptoms.The British journal of clinical psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.