ArticleeLife2020
Downregulation of the tyrosine degradation pathway extends
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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0cells of the map it votes in
31citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Methionine restriction and mimetics to ameliorate human aging and disease.Trends in endocrinology and metabolism: TEM · 2026Review
- ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity.Nature communications · 2026Article
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- Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.Nature communications · 2026Article
- Perturbation of NAD(P)H metabolism with theScience advances · 2026Article
- Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan.bioRxiv : the preprint server for biology · 2025Article
- An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan.PLoS genetics · 2025Article
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- Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner.Science advances · 2025Article
- Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases.Science advances · 2025Review
- Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila.bioRxiv : the preprint server for biology · 2025Article
- Distinct Urinary Metabolite Signatures Mirror In Vivo Oxidative Stress-Related Radiation Responses in Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Alterations in the gut microbiome and metabolism profiles reveal the possible molecular mechanism of renal injury induced by hyperuricemia in a mouse model of renal insufficiency.Renal failure · 2024Article
- Unique tau- and synuclein-dependent metabolic reprogramming in neurons distinct from normal aging.Aging cell · 2024Article
- Queen Bee Larva, an Edible By-Product of Royal Jelly, Alleviate D-Galactose-Induced Aging in Mouse by Regulating Gut Microbiota Structure and Amino Acid Metabolism.Antioxidants (Basel, Switzerland) · 2024Article
- De novo transcriptome assembly and differential gene expression analysis in different developmental stages of Agriotes sputator (click beetle).Scientific reports · 2024Article
- Context-dependent impact of the dietary non-essential amino acid tyrosine onScience advances · 2024Article
- Identification of Gut Microbiome Signatures Associated with Indole Pathway in Tryptophan Metabolism in Patients Undergoing Hemodialysis.Biomolecules · 2024Article
- Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models inbioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 3 countries.
Andrey A ParkhitkoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID 0000-0001-9852-8329
Divya RameshNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.ORCID 0000-0003-1387-7832
Lin WangDepartment of Chemistry, Princeton University, Princeton, United States.ORCID 0000-0002-9370-6891
Dmitry LeshchinerDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.
Elizabeth FilineDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.
Richard BinariDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.
Abby L OlsenDepartment of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, United States.
Valentin CracanScintillon Institute, San Diego, United States.ORCID 0000-0002-3280-0593
Joshua D RabinowitzDepartment of Chemistry, Princeton University, Princeton, United States.
Axel BrockmannNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.ORCID 0000-0003-0201-9656
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID 0000-0001-7542-472X
Harvard University · USHoward Hughes Medical Institute · USPrinceton University · USTata Institute of Fundamental Research · INBoston University · USBrigham and Women's Hospital · USScripps Research Institute · US
Funding
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MDrosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8MCharacterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2MDefining the genetic contribution of glia in Parkinson's disease pathogenesisK08NS109344 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OLSEN, ABBY LAUREN · 2018 to 2022
$997kStudying methionine flux and its role in aging and neurodegenerationR00AG057792 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARKHITKO, ANDREY A · 2020 to 2022
$871kEngineered flavin-dependent enzymes for probing redox environment and regulationR00GM121856 · NIGMS · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI CRACAN, VALENTIN · 2019 to 2021
$747kStudying methionine flux and its role in aging and neurodegenerationK99AG057792 · NIA · HARVARD MEDICAL SCHOOL · PI PARKHITKO, ANDREY A · 2018 to 2019
$198kNational Centre for Biological Sciences 12P4167NCI NIH HHS P01 CA120964NIAMS NIH HHS R01 AR057352NIA NIH HHS K99 AG057792NIA NIH HHS R00 AG057792NIGMS NIH HHS R00 GM121856NIGMS NIH HHS R01 GM084947NINDS NIH HHS K08 NS109344NINDS NIH HHS L30 NS108208
Abstract
Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived
Indexed as
AgingAnimalsDrosophila melanogasterElectron Transport Chain Complex ProteinsLongevityMitochondriaTigecyclineTyrosineTyrosine TransaminaseElectron Transport Chain Complex ProteinsTigecyclineTyrosineTyrosine TransaminaseD. melanogasterETC Complex IgeneticsgenomicsmitochondrianeurotransmittersTATtigecyclinetyrosine aminotransferase
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.