Evidence map›Paper›PMID 33319744›Full record

ArticleeLife2020

Comprehension of computer code relies primarily on domain-general executive brain regions.

Anna A Ivanova, Shashank Srikant, Yotaro Sueoka, Hope H Kean, Riva Dhamala, Una-May O'Reilly, Marina U Bers, Evelina Fedorenko

Open access · goldAbstract readComparative Study
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The Extended Language Network: Language-Responsive Brain Areas Whose Contributions to Language Remain To Be Discovered.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  7. Learning to Program "Recycles" Preexisting Frontoparietal Population Codes of Logical Algorithms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  8. Article
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  10. Article
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  14. Early-emerging combinatorial thought: Human infants flexibly combine kind and quantity concepts.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anna A IvanovaDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-1184-8299
Shashank SrikantComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, United States.
Yotaro SueokaDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-6417-9052
Hope H KeanDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
Riva DhamalaEliot-Pearson Department of Child Study and Human Development, Tufts University, Medford, United States.
Una-May O'ReillyComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, United States.
Marina U BersEliot-Pearson Department of Child Study and Human Development, Tufts University, Medford, United States.ORCID 0000-0003-0206-1846
Evelina FedorenkoDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0003-3823-514X
McGovern Institute for Brain Research · USMassachusetts Institute of Technology · USTufts University · US

Funding

National Science Foundation #1744809
6 · The paper itself

Abstract

Computer programming is a novel cognitive tool that has transformed modern society. What cognitive and neural mechanisms support this skill? Here, we used functional magnetic resonance imaging to investigate two candidate brain systems: the multiple demand (MD) system, typically recruited during math, logic, problem solving, and executive tasks, and the language system, typically recruited during linguistic processing. We examined MD and language system responses to code written in Python, a text-based programming language (Experiment 1) and in ScratchJr, a graphical programming language (Experiment 2); for both, we contrasted responses to code problems with responses to content-matched sentence problems. We found that the MD system exhibited strong bilateral responses to code in both experiments, whereas the language system responded strongly to sentence problems, but weakly or not at all to code problems. Thus, the MD system supports the use of novel cognitive tools even when the input is structurally similar to natural language.

Indexed as

CognitionComprehensionExecutive FunctionSoftwareAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysYoung Adultcomputer codefMRIhumanlanguagemultiple demandneuroscienceprogramming

Identifiers

PMID33319744
PMCPMC7738192
OpenAlexW3111309488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.