ArticleJournal of diabetes investigation2021
Association between the triglyceride-glucose index and diabetic nephropathy in patients with type 2 diabetes: A cross-sectional study.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association between the triglyceride glucose index and diabetic retinopathy in type 2 diabetes: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Triglyceride-glucose index, neutrophil-to-lymphocyte ratio, and high-sensitivity C-reactive protein across albuminuria stages in type 2 diabetes.Scientific reports · 2026Article
- Triglyceride-Glucose Index and Risk of End-Stage Kidney Disease in Young Adults: National Population-Based Cohort Study.JMIR public health and surveillance · 2026Article
- Nonlinear Association of the Triglyceride-Glucose Index With Hyperuricemia Among Young Chinese Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Article
- Triglyceride-glucose index, genetic susceptibility, and trajectory of microvascular multimorbidity in type 2 diabetes.Scientific reports · 2026Article
- Sex-Specific Predictive Value of Obesity-Related Indicators for Diabetic Kidney Disease in Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Stress hyperglycemia ratio (SHR) and triglyceride-glucose index (TYG) associated with renal response to finerenone in diabetic kidney disease: a retrospective cohort study.Frontiers in medicine · 2026Article
- Association between triglyceride-glucose (TyG) index and diabetic foot ulcers in adult inpatients with type 2 diabetes at hospital admission.Frontiers in clinical diabetes and healthcare · 2026Article
- Association of triglyceride-glucose index and high-sensitivity C-reactive protein with contrast-induced nephropathy after percutaneous coronary intervention in patients with acute coronary syndrome: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Association of triglyceride glucose index with cardiovascular autonomic neuropathy in type 2 diabetes mellitus.Frontiers in cardiovascular medicine · 2026Article
- Reassessment-stage metabolic indices and subsequent cardiorenal outcomes in adults with diabetes: CHARLS and an independent hospital validation cohort.Frontiers in endocrinology · 2026Article
- Association of triglyceride-glucose index with diabetic kidney disease in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Lumican as a potential biomarker for diabetic nephropathy.Renal failure · 2025Article
- Evaluation of the Relationship Between Albuminuria and Triglyceride Glucose Index in Patients with Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Correlation of Triglyceride-Glucose Index and the Presence of Microvascular Complications of Diabetes.Cureus · 2025Article
- Association between Triglyceride-Glucose index and onset of type 2 diabetes in metabolic Dysfunction-Associated steatotic liver disease population.Scientific reports · 2025Article
- Prevalence and risk factors of diabetic nephropathy among type 2 diabetes patients in family medicine clinic AFHSR Khamis Mushait.Journal of family medicine and primary care · 2025Article
- Elevated waist-to-hip ratio, as an abdominal obesity index, predicts the risk of diabetic kidney injury.World journal of diabetes · 2025Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
AIMS/
introductionThe triglyceride-glucose (TyG) index has been proposed as a reliable and simple marker of insulin resistance. We investigated the association between TyG index and diabetic nephropathy (DN) in patients with type 2 diabetes. MATERIALS AND
methodsA consecutive case series of 682 adult patients with type 2 diabetes hospitalized in the Department of Endocrinology at the Tongji Hospital (Wuhan, Hubei, China) from January 2007 to December 2009 was included in this cross-sectional analysis. Receiver operating characteristics curve analysis, correlation analysis and multiple logistic regression analysis were carried out.
resultsA total of 232 (34.0%) participants were identified with DN. Compared with the non-DN group, the DN group had longer disease duration, and higher bodyweight, systolic blood pressure, diastolic blood pressure, glycated hemoglobin, triglycerides, total cholesterol, serum uric acid, 24 h-urinary albumin, TyG index and homeostasis model assessment 2 estimates for insulin resistance (HOMA2-IR; P < 0.05 for each). The TyG index with an optimal cut-off point >9.66 showed a higher area under the receiver operating characteristic curve of 0.67 (P = 0.002) than HOMA2-IR (area under the curve 0.61, P = 0.029) on receiver operating characteristic curve analysis for DN identification. Additionally, the TyG index positively correlated with the levels of metabolic indicators (bodyweight, glycated hemoglobin, triglycerides, total cholesterol, serum uric acid, fasting glucose and HOMA2-IR) and natural logarithmic 24 h-urinary albumin (P < 0.05 for each), but not natural logarithm of estimated glomerular filtration rate. On multiple regression analysis, an increased TyG index was shown to be an independent risk factor (odds ratio 1.91, P = 0.001) for DN.
conclusionsThe TyG index was independently associated with DN in patients with type 2 diabetes, and was a better marker than HOMA2-IR for identification of DN in type 2 diabetes patients.
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