Evidence map›Paper›PMID 33319483›Full record

ArticleStress and health : journal of the International Society for the Investigation of Stress2021

Association between symptoms of psychological distress and cognitive functioning among adults with coronary artery disease.

Kasra Moazzami, Mariana Garcia, An Young, Zakaria Almuwaqqat, Bruno B Lima, Afif Martini, Mhmtjamil Alkhalaf, Amit J Shah, Felicia C Goldstein, Ihab Hajjar and 4 more

Open access · greenAbstract read
In one paragraph

Article in Stress and health : journal of the International Society for the Investigation of Stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kasra MoazzamiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-0328-2050
Mariana GarciaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
An YoungDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Zakaria AlmuwaqqatDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Bruno B LimaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Afif MartiniDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Mhmtjamil AlkhalafDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Amit J ShahDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Felicia C GoldsteinDepartment of Neurology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA.
Ihab HajjarDepartment of Neurology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA.
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA.
J Douglas BremnerAtlanta VA Medical Center, Decatur, Georgia, USA.
Arshed A QuyyumiDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Viola VaccarinoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Emory University · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Vascular Responses During Mental StressP01HL101398 · NHLBI · EMORY UNIVERSITY · PI QUYYUMI, ARSHED A · 2010 to 2015
$11.0M
Mental Stress and Myocardial Ischemia after MI: Sex Differences, Mechanisms and PrognosisR01HL109413 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2012 to 2023
$6.9M
Multidisciplinary Research Training to Reduce Inequities in Cardiovascular HealthT32HL130025 · NHLBI · EMORY UNIVERSITY · PI Tené T Lewis, Viola Vaccarino · 2016 to 2026
$6.4M
Neural Circuits in Women with Abuse and PTSDR01MH056120 · NIMH · YALE UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 1999 to 2011
$5.0M
PTSD and Ischemic Heart Disease Progression: A Longitudinal Twin StudyR01HL125246 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2015 to 2018
$3.4M
Dopamine function, inflammation and connectivity in PTSDR01MH120262 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2020 to 2023
$2.9M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalKL2TR000455 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$2.9M
Mechanisms of Depression in CVDR01HL088726 · NHLBI · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2008 to 2012
$2.6M
Mind-Body Interactions in Cardiovascular DiseaseK24HL077506 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2004 to 2013
$1.5M
Biological Correlates of Traumatic StressK24MH076955 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2006 to 2013
$946k
Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use Disorders UG3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2020 to 2021
$844k
NCATS NIH HHS KL2 TR000455NCATS NIH HHS UL1 TR000454NHLBI NIH HHS F32 HL151163NHLBI NIH HHS K23 HL127251NHLBI NIH HHS K24 HL077506NHLBI NIH HHS P01 HL101398NHLBI NIH HHS R01 HL088726NHLBI NIH HHS R01 HL109413NHLBI NIH HHS R01 HL125246NHLBI NIH HHS T32 HL130025NIDA NIH HHS UG3 DA048502NIH Clinical Center P01HL101398, R01HL109413, R01HL109413-02S1, R01HL1NIMH NIH HHS K24 MH076955NIMH NIH HHS R01 MH056120NIMH NIH HHS R01 MH120262RRD VA I01 RX003418
6 · The paper itself

Abstract

Greater psychological distress is associated with cognitive impairment in healthy adults. Whether such associations also exist in patients with coronary artery disease (CAD) is uncertain. We assessed cognitive function in 496 individuals with CAD using the verbal and visual memory subtests of the Wechsler Memory Scale and executive functioning measured by the Trail Making Test Parts A and B. We used a composite score of psychological distress derived through summation of Z-transformed psychological distress symptom scales (depression, posttraumatic stress, anxiety, anger, hostility and perceived stress) and scores for each individual psychological scale. Multivariable linear regression models were used to determine the association between memory scores (as outcomes) and the psychological distress scores (both composite score and individual scales). After adjusting for demographic and cardiovascular risk factors, a higher psychological distress score was independently associated with worse memory and executive functioning. Each standard deviation increase in psychological distress score was associated with 3% (95% confidence interval [CI], 1%-5%) to 5% (95% CI, 3-7%) worse cognitive performance (higher Trail A and Trail B, and lower verbal and visual memory scores). Among individuals with CAD, a higher level of psychological distress is independently associated with worse cognitive performance. These findings suggest that psychological risk factors play a role in cognitive trajectories of persons with CAD.

Indexed as

Cognitive DysfunctionCoronary Artery DiseasePsychological DistressAdultHumansRisk Factorscognitive impairmentcoronary artery diseasepsychological distress

Identifiers

PMID33319483
PMCPMC8395370
OpenAlexW3111270507

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.