Evidence map›Paper›PMID 33319418›Full record

ArticleExperimental dermatology2021

High-resolution single-cell transcriptomics reveals heterogeneity of self-renewing hair follicle stem cells.

Gopal Chovatiya, Sangeeta Ghuwalewala, Lauren D Walter, Benjamin D Cosgrove, Tudorita Tumbar

Open access · greenAbstract read
In one paragraph

Article in Experimental dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. An updated guide to hair follicle stem cell markers and changes in their expression with aging.JID innovations : skin science from molecules to population health · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Generation of theInternational journal of molecular sciences · 2025
    Article
  10. Article
  11. Review
  12. Interpretation of the Yak Skin Single-Cell Transcriptome Landscape.Animals : an open access journal from MDPI · 2023
    Article
  13. Alk1 acts in non-endothelial VE-cadherinNature communications · 2023
    Article
  14. Review
  15. [Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. iPSC-based approach for human hair follicle regeneration.Frontiers in cell and developmental biology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gopal ChovatiyaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-0993-8877
Sangeeta GhuwalewalaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Lauren D WalterDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Benjamin D CosgroveMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Tudorita TumbarDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Cornell University · US

Funding

Tissue regeneration studies by controlled H3 K4/9/27me3 levels in adult mouse skinR01AR073806 · NIAMS · CORNELL UNIVERSITY · PI JOHN T LIS, Tudorita Tumbar · 2018 to 2026
$3.9M
Defining the heterogeneity of cell lineages in the inter-follicular epidermisR01AR070157 · NIAMS · CORNELL UNIVERSITY · PI Tudorita Tumbar · 2017 to 2026
$3.8M
Revealing muscle stem cell heterogeneity in mice and humans through deep single-cell analysisR01AG058630 · NIA · CORNELL UNIVERSITY · PI COSGROVE, BENJAMIN DAVID · 2018 to 2022
$2.9M
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
A Light Sheet Microscope for the Cornell BRC Imaging FacilityS10OD023466 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2017 to 2017
$364k
NCRR NIH HHS S10 RR025502NIAMS NIH HHS R01 AR070157NIAMS NIH HHS R01 AR073806NIA NIH HHS R01 AG058630NIH HHS S10 OD023466
6 · The paper itself

Abstract

Multipotent bulge stem cells (SCs) fuel the hair follicle (HF) cyclic growth during adult skin homeostasis, but their intrinsic molecular heterogeneity is not well understood. These hair follicle stem cells (HFSCs) engage in bouts of self-renewal, migration and differentiation during the hair cycle. Here, we perform high-resolution single-cell RNA sequencing (scRNA-seq) of HFSCs sorted as CD34

Indexed as

Skin Physiological PhenomenaAnimalsAntigens, CD34Hair FollicleMaleMiceSkinStem CellsTranscriptomeAntigens, CD34BulgeGSEAhair follicle stem cellsORSQuiescencescRNA-seq

Identifiers

PMID33319418
PMCPMC8016723
OpenAlexW3111049768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.