ArticleKidney medicine
Neutrophil Activation and Neutrophil Extracellular Trap Formation in Dialysis Patients.
Article in Kidney medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Randomized investigation of increased dialyzer membrane hydrophilicity on hemocompatibility and performance.BMC nephrology · 2024Trial
- Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis.World journal of clinical pediatrics · 2026Article
- The Vicious Cycle of Inflammation: How Obesity, Dialysis Catheters, and NETosis Determine Albumin Levels and Prognosis in Hemodialysis Patients.International journal of molecular sciences · 2026Article
- Neutrophil extracellular traps drive peritoneal inflammation and tissue remodeling in pediatric peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Differential effects of hemodialysis modalities on circulating neutrophil extracellular traps in children on maintenance hemodialysis: a cohort study.Scientific reports · 2025Article
- Hemodiafiltration Attenuates NETosis Compared With High-Flux Hemodialysis in End-Stage Kidney Disease Patients.Kidney international reports · 2025Article
- Review
- A Critical Role of Neutrophil-Driven Amplification of Chronic Microinflammation in the Biocompatibility of Hemodialysis.International journal of molecular sciences · 2025Review
- Effects of Diet and Supplements on Parameters of Oxidative Stress, Inflammation, and Antioxidant Mechanisms in Patients with Chronic Renal Failure Undergoing Hemodialysis.International journal of molecular sciences · 2024Article
- The Complex Immunological Alterations in Patients with Type 2 Diabetes Mellitus on Hemodialysis.Journal of clinical medicine · 2024Review
- The Relationship Between Plasma Gelsolin Levels and Myeloperoxidase in Patients Undergoing Hemodialysis: A Prospective, Observational, Controlled Study.Journal of clinical practice and research · 2024Article
- The Janus-faced nature of complement in hemodialysis: interplay between complement, inflammation, and bioincompatibility unveiling a self-amplifying loop contributing to organ damage.Frontiers in nephrology · 2024Article
- Tacrolimus Maintains the Balance of Neutrophil Extracellular Traps by Inducing DNA Methylation of Neutrophils to Reduce Immune Rejection.Life (Basel, Switzerland) · 2023Article
- What is the role of the neutrophil extracellular traps in the cardiovascular disease burden associated with hemodialysis bioincompatibility?Frontiers in medicine · 2023Review
- Extracellular DNA concentrations in various aetiologies of acute kidney injury.Scientific reports · 2022Article
- Immune System Dysfunction and Inflammation in Hemodialysis Patients: Two Sides of the Same Coin.Journal of clinical medicine · 2022Review
- Association between subclinical left ventricular ejection fraction and platelet-to-lymphocyte ratio in patients with peritoneal dialysis.Frontiers in medicine · 2022Article
- Article
- Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE &
objectiveThe removal of metabolic waste by passing blood through synthetic tubing and membranes generates an immune response, even with the most biocompatible materials available. We evaluated blood levels of neutrophil activation and cell death during dialysis to devise a set of markers by which future dialysis interventions might be measured for biocompatibility. STUDY
designObservational, case control. SETTING &
participants30 patients with end-stage kidney disease in Seattle, WA, evaluated during 30 dialysis procedures in out- and inpatient settings were compared with 27 healthy (negative) controls and 20 nondialysis patients with systemic lupus erythematosus as positive controls. PREDICTORS: Blood levels of neutrophil activation (calprotectin and peroxidase activity) and cell death (cell-free DNA and neutrophil extracellular traps) were assayed. OUTCOMES: Markers of neutrophil activation and cell death can be used to assess immune response during dialysis. ANALYTICAL APPROACH: Descriptive analysis and group comparisons.
resultsIntradialytic levels of neutrophil activation markers are higher than prehemodialysis levels ( LIMITATIONS: Low sample size with heterogeneous patient cohort.
conclusionsNeutrophil activation occurs during hemodialysis, potentially contributing to endothelial inflammation and damage. Neutrophil activation markers are novel and sensitive measures of biocompatibility for improving dialysis.
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Registered trials
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