Evidence map›Paper›PMID 33318950›Full record

ArticleToxicology reports2020

Subacute oral toxicity of ayurvedic anti-diabetic preparation

Mahedi Hasan, Abdullah Al Mahmud, Md Jahir Alam, Shafayet Ahmed Siddiqui, Md Saiful Islam Arman, Muhammed Hasan Mahmud, Mohammad Nurul Amin, Omar Imtiaz, Masum Shahriar, Md Jakaria

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Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Mahedi HasanDepartment of Pharmacy, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Abdullah Al MahmudDepartment of Pharmacy, Manarat International University, Ashulia Model Town, Khagan, Ashulia, Dhaka, Bangladesh.
Md Jahir AlamDepartment of Pharmacy, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Shafayet Ahmed SiddiquiDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.
Md Saiful Islam ArmanDepartment of Pharmacy, International Islamic University Chittagong, Chattogram, 4318, Bangladesh.
Muhammed Hasan MahmudDepartment of Pharmacy, International Islamic University Chittagong, Chattogram, 4318, Bangladesh.
Mohammad Nurul AminDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230, Bangladesh.
Omar ImtiazDepartment of Pharmacy, Manarat International University, Ashulia Model Town, Khagan, Ashulia, Dhaka, Bangladesh.
Masum ShahriarDepartment of Pharmacy, Jahangirnagar University, Savar, Dhaka, 1342, Bangladesh.
Md JakariaMelbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.
Jahangirnagar University · BDAtish Dipankar University of Science and Technology · BDInternational Islamic University Chittagong · BDManarat International University · BDFlorey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJambadyarista is an Ayurvedic polyherbal formulation widely prescribed by Ayurvedic practitioners for the management of diabetes and its associated complications. About 39 companies have marketed this formulation in Bangladesh with consent from the Directorate General of Drug Administration (DGDA).

aimThis study investigated the sub-acute oral toxicity of Jambadyarista in the Sprague-Dawley rat model.

methodsThe sub-acute toxicity studies were executed in Sprague-Dawley rats. Jambadyarista formulation was given for 28-days through oral gavage at 10 mL/kg and 20 mL/kg dose to two different groups comprising 6 rats of both sex/groups. Across the experimental period mortality, adverse reactions were closely monitored. After 28-day feeding hematological, biochemical, and relative organ weights were quantified.

resultsNo mortality and/or signs of morbidity were observed for 28-day of repeated-dose sub-acute toxicity. Any pernicious change in body weight, biochemical, and hematological parameters along with relative organ weight were not observed for Jambadyarista. Correlation study among parameters of the renal profile, liver profile, lipid profile also metabolic hormones (T

conclusionJambadyarista preparation did not cause any potential toxic effect in repeated dose subacute toxicity study over Sprague-Dawley rats orally. Therefore, low dose administration of Jambadyarista could have a beneficial effect on diabetes and can be considered safe before the chronic study.

Indexed as

AyurvedicBiochemical parametersHematological parametersJambadyaristaSub acute toxicity

Identifiers

PMID33318950
PMCPMC7725955
OpenAlexW3110252832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.