Evidence map›Paper›PMID 33318876›Full record

ReviewJournal of advanced research2021

Targeting hydrogen sulphide signaling in breast cancer.

Rana Ahmed Youness, Ahmed Zakaria Gad, Khaled Sanber, Yong Jin Ahn, Gi-Ja Lee, Emad Khallaf, Hafez Mohamed Hafez, Amira Abdel Motaal, Nabil Ahmed, Mohamed Zakaria Gad

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. A universal consuming endogenous HBioactive materials · 2027
    Article
  3. The multifaceted role of 3-methyladenine in cancer therapy.Journal of physiology and biochemistry · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. HCNS neuroscience & therapeutics · 2025
    Article
  16. Article
  17. SQOR as a metabolic rheostat of HFrontiers in cell and developmental biology · 2025
    Review
  18. Review
  19. Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer.Redox report : communications in free radical research · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Rana Ahmed YounessDepartment of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.
Ahmed Zakaria GadInterdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Khaled SanberCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.
Yong Jin AhnDepartment of Medical Engineering, Graduate School, Kyung Hee University, Seoul 130-701, Republic of Korea.
Gi-Ja LeeDepartment of Medical Engineering, Graduate School, Kyung Hee University, Seoul 130-701, Republic of Korea.
Emad KhallafDepartment of General Surgery, Faculty of Medicine, Cairo University, 12613 Cairo, Egypt.
Hafez Mohamed HafezDepartment of General Surgery, Faculty of Medicine, Cairo University, 12613 Cairo, Egypt.
Amira Abdel MotaalDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Nabil AhmedInterdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Mohamed Zakaria GadDepartment of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.
Cairo University · EGHouston Methodist · USGerman University in Cairo · EGKyung Hee University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHydrogen sulphide (H

objectivesThis study investigated the role of H

methodsEighty BC patients have been recruited for the study. BC cell lines were cultured and transfected using validated oligonucleotide delivery system. Gene and protein expression analysis was performed using qRT-PCR, western blot and flow-cytometry.

resultsThe H

conclusionThese findings demonstrate the potential role of H

Indexed as

41BBL, 41BB Ligand51Cr-release, Chromium release assayBC, Breast CancerBreast cancerCAR, Chimeric antigen receptorCAR T cellsCBS, Cystathionine β-synthaseCD80, Cluster of differentiation 80CD86, Cluster of differentiation 86CSE, Cystathionine γ-lyaseCTL, Cytotoxic T lymphocyteH2S, Hydrogen sulphideHCC, Hepatocellular carcinomaHLA-DR, Human Leukocytic antigen DRHydrogen sulphideIFN-γ, Interferon gammaKD, Knock downLDH, Lactate dehydrogenase AssayMICA/B, MHC class I polypeptide-related sequence A/BmiR-155/NOS2/NO signaling pathwaymiR-4317miRNA, MicroRNANatural killer cellsncRNAs, Non-coding RNAsNitric oxideNKG2D, Natural Killer Group 2DNK, Natural killerNO, Nitric oxideNOS2, Inducible nitric oxide synthase-2NOS3, Endothelial nitric oxide synthase-3PD-L1, Programmed death-ligand 1PI3K/AKT signaling pathwayScr-miRNAs, Scrambled microRNAsScr-siRNAs, Scrambled siRNAssiRNAs, Small interfering RNAsTNBC, Triple negative breast cancerTNF-α, Tumor necrosis factor-αULBP2/5/6, UL16 binding protein 2/5/6

Identifiers

PMID33318876
PMCPMC7728592
OpenAlexW3042737539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.