Evidence map›Paper›PMID 33318872›Full record

ReviewJournal of advanced research2021

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential.

Hai-Jian Sun, Zhi-Yuan Wu, Xiao-Wei Nie, Xin-Yu Wang, Jin-Song Bian

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. HFrontiers in cell and developmental biology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  15. Review
  16. Endothelial HRedox biology · 2024
    Article
  17. Selenium-Based Catalytic Scavengers for Concurrent Scavenging of HAngewandte Chemie (International ed. in English) · 2024
    Article
  18. Article
  19. Article
  20. Role of Hydrogen Sulfide and Hypoxia in Hepatic Angiogenesis of Portal Hypertension.Journal of clinical and translational hepatology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hai-Jian SunDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
Zhi-Yuan WuDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
Xiao-Wei NieDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
Xin-Yu WangDepartment of Endocrinology, The First Affiliated Hospital of Shenzhen University (Shenzhen Second People's Hospital), Shenzhen 518037, China.
Jin-Song BianDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
National University of Singapore · SGShenzhen Second People's Hospital · CNSuzhou Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the last several decades, hydrogen sulfide (H AIM OF REVIEW: In the present review, we will highlight the recent advancements in the cellular events triggered by H KEY SCIENTIFIC CONCEPTS OF REVIEW: As a critical regulator of liver functions, H

Indexed as

3-MP, 3-mercaptopyruvate3-MST, 3-mercaptopyruvate sulfurtransferaseAGTR1, angiotensin II type 1 receptorAkt, protein kinase BAMPK, AMP-activated protein kinaseCancerCAT, cysteine aminotransferaseCBS, cystathione β-synthaseCO, carbon monoxideCOX-2, cyclooxygenase-2CSE, cystathione γ-lyaseCX3CR1, chemokine CX3C motif receptor 1DAO, D-amino acid oxidaseDATS, Diallyl trisulfideEGFR, epidermal growth factor receptorERK, extracellular regulated protein kinasesFAS, fatty acid synthaseFibrosisH2S, hydrogen sulfideHFD, high fat dietHO-1, heme oxygenase 1Hydrogen sulfideIR, ischemia/reperfusionLiver diseaseMMP-2, matrix metalloproteinase 2mTOR, mammalian target of rapamycinNADH, nicotinamide adenine dinucleotideNADPH, nicotinamide adenine dinucleotide phosphateNAFLD, non-alcoholic fatty liver diseasesNaHS, sodium hydrosulfideNASH, nonalcoholic steatohepatitisNF-κB, nuclear factor-kappa BNrf2, nuclear factor erythroid2-related factor 2PI3K, phosphatidylinositol 3-kinasePLP, pyridoxal 5′-phosphatePPG, propargylglycinePTEN, phosphatase and tensin homolog deleted on chromosome tenSAC, S-allyl-cysteineSPRC, S-propargyl-cysteineSTAT3, signal transducer and activator of transcription 3SteatosisVLDL, very low density lipoprotein

Identifiers

PMID33318872
PMCPMC7728580
OpenAlexW3025550252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.