Evidence map›Paper›PMID 33318778›Full record

ArticleRadiology case reports2021

Second trimester fetal MRI features in a fetus with TUBB3 gene mutation.

Mounika Guduru, Andria Powers, Terri Love, Angela Beavers

Erratum issuedOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mounika GuduruDepartment of Radiology, Creighton University, Omaha, NE, USA.
Andria PowersDepartment of Pediatric Radiology, Children's Hospital and Medical Center, University of Nebraska Medical Center, 42nd and, Emile St, Omaha, NE 68198 USA.
Terri LoveDepartment of Pediatric Radiology, Children's Hospital and Medical Center, University of Nebraska Medical Center, 42nd and, Emile St, Omaha, NE 68198 USA.
Angela BeaversDepartment of Pediatric Radiology, Children's Hospital and Medical Center, University of Nebraska Medical Center, 42nd and, Emile St, Omaha, NE 68198 USA.
University of Nebraska Medical Center · USChildren's Hospital & Medical Center · USCreighton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tubulinopathies are a heterogeneous group of complex cortical malformations that are associated with mutations in tubulin genes. TUBB3 gene mutation is associated with a broader spectrum of central nervous system malformations and constitutes about 10% of all tubulinopathies. The diagnosis may not be immediately apparent on imaging, though the differential diagnosis may be narrowed based on imaging findings and allow for more directed genetic testing. We report a 22-year-old gravida-1 nulliparous female whose routine second trimester fetal ultrasound revealed ventriculomegaly and possible agenesis of the corpus callosum. Fetal magnetic resonance imaging showed severe lateral and third ventriculomegaly and a dysplastic, z-shaped brainstem without any evidence of ocular abnormalities. Genetic testing revealed a pathogenic mutation in TUBB3.

Indexed as

Brain malformationBrainstem kinkingCerebellar hypoplasiaFetal ventriculomegalyTUBB3 mutationTubulinopathy

Identifiers

PMID33318778
PMCPMC7726483
OpenAlexW3113111354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.