ReviewNature reviews. Neurology2021
Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies.
Review in Nature reviews. Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 399 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electro-acupuncture to Treat Disorder of Consciousness
Evaluation of EEG Power Spectrum in Patients With Traumatic Coma
Family-Centered Affective Stimulation for Patients With Traumatic Brain Injury: Its Effects on Coma Recovery
Who cites it
399 citing papers in PubMed, 7 syntheses or guidelines pooled it, 654 citations in OpenAlex.
- Efficacy of transcranial direct current stimulation for disorders of consciousness: an updated systematic review and meta-analysis based on sham-controlled randomized trials.Frontiers in neuroscience · 2026Pooled it
- Noninvasive neuromodulation for disorders of consciousness: an updated systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Effects of non-invasive brain stimulation on arousal and alertness among traumatic brain injury patients with disorders of consciousness or persistent vegetative State: a systematic review.Acta neurologica Belgica · 2025Pooled it
- Knowledge mapping and research trends on rehabilitation of patients with mechanical ventilation in the ICU from 2005 to 2024: a bibliometric analysis via CiteSpace and Bibliometrix.Frontiers in neurology · 2025Pooled it
- Pooled it
- Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review.CNS neuroscience & therapeutics · 2024Pooled it
- Predicting outcome in disorders of consciousness: A mega-analysis.Annals of clinical and translational neurology · 2024Pooled it
- Promoting Consciousness Recovery in Patients with Acquired Brain Injury Through Multimodal Sensory Stimulation: A Randomized Controlled Trial of Median Nerve and Auricular Stimulation.Neurocritical care · 2026Trial
- Efficacy of Intermittent Theta-Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial.Annals of clinical and translational neurology · 2026Trial
- Clinical efficacy of electroacupuncture stimulation based on mismatch negativity in patients with prolonged disorders of consciousness.Arquivos de neuro-psiquiatria · 2026Trial
- Repeated tDCS of the left dorsolateral prefrontal cortex for acute DoC: a pilot randomized controlled trial.Scientific reports · 2026Trial
- Effect of cerebellar stimulation on awareness recovery in disorders of consciousness (CARE-DoC): A randomized, sham-controlled, crossover clinical trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Trial
- Can repetitive transcranial magnetic stimulation promote recovery of consciousness in patients with disorders of consciousness? A randomized controlled trial.NeuroImage. Clinical · 2025Trial
- Efficacy of melatonin for prolonged disorders of consciousness: a double-blind, randomized clinical trial.BMC medicine · 2024Trial
- Perturbational complexity index in assessing responsiveness to rTMS treatment in patients with disorders of consciousness: a cross-over randomized controlled trial study.Journal of neuroengineering and rehabilitation · 2024Trial
- Impact of a Specialized Care Pathway for ICU Patients With Disorders of Consciousness: Observational Insights From an Expert Center.European journal of neurology · 2026Observational
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- EEG functional connectivity measures for differentiating 6-month consciousness-related outcome after brain injury.BMC medical imaging · 2026Article
- Deep Brain Stimulation for Disorders of Consciousness: From Mesocircuit Mechanisms to Circuit-Guided Precision Neuromodulation.Neuroscience bulletin · 2026Review
339 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Substantial progress has been made over the past two decades in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DoC) caused by severe brain injuries. Advanced neuroimaging and electrophysiological techniques have revealed new insights into the biological mechanisms underlying recovery of consciousness and have enabled the identification of preserved brain networks in patients who seem unresponsive, thus raising hope for more accurate diagnosis and prognosis. Emerging evidence suggests that covert consciousness, or cognitive motor dissociation (CMD), is present in up to 15-20% of patients with DoC and that detection of CMD in the intensive care unit can predict functional recovery at 1 year post injury. Although fundamental questions remain about which patients with DoC have the potential for recovery, novel pharmacological and electrophysiological therapies have shown the potential to reactivate injured neural networks and promote re-emergence of consciousness. In this Review, we focus on mechanisms of recovery from DoC in the acute and subacute-to-chronic stages, and we discuss recent progress in detecting and predicting recovery of consciousness. We also describe the developments in pharmacological and electrophysiological therapies that are creating new opportunities to improve the lives of patients with DoC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.