ArticleScientific reports2020
Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- The effects of progesterone supplementation in pregnancies assessed by doppler ultrasound: a systematic review of maternal and perinatal outcomes.European journal of medical research · 2025Pooled it
- Periconceptional biomarkers for maternal obesity: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Prenatal Constant Light Exposure Induces Behavioral Deficits in Male and Female Rat Offspring: Effects of Prenatal Melatonin Treatment.International journal of molecular sciences · 2025Article
- Vaginal Progesterone Effects on Ultrasound Indices, Fetal Outcomes, and Preeclampsia in High-risk Pregnancy : Vaginal Progesterone in High-risk Pregnancy: Ultrasound Indices and Outcomes.Galen medical journal · 2025Article
- Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.EMBO reports · 2024Article
- A Single Administration of Progesterone during the Neonatal Period Shows No Structural Changes in Male Reproductive Tracts in Mice.Acta histochemica et cytochemica · 2023Article
- In Utero Exposure to Hormonal Contraception and Mortality in Offspring with and without Cancer: A Nationwide Cohort Study.Cancers · 2023Article
- Did the NICE guideline for progesterone treatment of threatened miscarriage get it right?Reproduction & fertility · 2022Article
- Impact of Endocrine Disruptors upon Non-Genetic Inheritance.International journal of molecular sciences · 2022Review
- The Role of Maternal and Environmental Factors During Pregnancy on the Risk of Hypospadias Occurrence.Global pediatric health · 2022Article
- Sex Differences Are Here to Stay: Relevance to Prenatal Care.Journal of clinical medicine · 2021Review
- Early-Pregnancy Dydrogesterone Supplementation Mimicking Luteal-Phase Support in ART Patients Did Not Provoke Major Reproductive Disorders in Pregnant Mice and Their Progeny.International journal of molecular sciences · 2021Article
- The inadequate corpus luteum.Reproduction & fertility · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We hypothesised that maternal early pregnancy progesterone supplementation would increase fetal progesterone, affect progesterone target tissues in the developing fetal reproductive system and be metabolised to other bioactive steroids in the fetus. We investigated the effects of progesterone treatment during early pregnancy on maternal and fetal plasma progesterone concentrations, transcript abundance in the fetal pituitary and testes and circulating steroids, at day 75 gestation, using a clinically realistic ovine model. Endogenous progesterone concentrations were lower in male than female fetuses. Maternal progesterone administration increased male, but not female, fetal progesterone concentrations, also increasing circulating 11-dehydrocorticosterone in male fetuses. Maternal progesterone administration altered fetal pituitary and testicular function in ovine male fetuses. This suggests that there may be fetal sex specific effects of the use of progesterone in early pregnancy, and highlights that progesterone supplementation should be used only when there is clear evidence of efficacy and for as limited time as necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.