Evidence map›Paper›PMID 33318557›Full record

Trial reportScientific reports2020

Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol.

Corey Horien, Scuddy Fontenelle, Kohrissa Joseph, Nicole Powell, Chaela Nutor, Diogo Fortes, Maureen Butler, Kelly Powell, Deanna Macris, Kangjoo Lee and 6 more

Abstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Resting state functional brain connectivity in child and adolescent psychiatry: where are we now?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Corey HorienInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA. corey.horien@yale.edu.
Scuddy FontenelleYale Child Study Center, New Haven, CT, USA.
Kohrissa JosephYale Child Study Center, New Haven, CT, USA.
Nicole PowellYale Child Study Center, New Haven, CT, USA.
Chaela NutorYale Child Study Center, New Haven, CT, USA.
Diogo FortesYale Child Study Center, New Haven, CT, USA.
Maureen ButlerYale Child Study Center, New Haven, CT, USA.
Kelly PowellYale Child Study Center, New Haven, CT, USA.
Deanna MacrisYale Child Study Center, New Haven, CT, USA.
Kangjoo LeeDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Abigail S GreeneInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
James C McPartlandYale Child Study Center, New Haven, CT, USA.
Fred R VolkmarYale Child Study Center, New Haven, CT, USA.
Dustin ScheinostInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Katarzyna ChawarskaYale Child Study Center, New Haven, CT, USA.
R Todd ConstableInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$11.5M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32GM007205NIH HHS P50MH115716NIMH NIH HHS P50 MH115716
6 · The paper itself

Abstract

Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7-17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings.

Indexed as

Magnetic Resonance ImagingAdolescentChildFemaleHumansMale

Identifiers

PMID33318557
PMCPMC7736342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.