Evidence map›Paper›PMID 33318317›Full record

Trial reportAging2020

Mental awareness improved mild cognitive impairment and modulated gut microbiome.

Wei Wei Thwe Khine, Miao Lian Voong, Ted Kheng Siang Ng, Lei Feng, Grishma Avinash Rane, Alan Prem Kumar, Ee Heok Kua, Ratha Mahendran, Rathi Mahendran, Yuan-Kun Lee

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05859230 (A Study of a Probiotic), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05859230 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Study of a Probiotic (Lacticaseibacillus Paracasei Strain Shirota) Intervention on Gut Microbiota and Cognitive Functioning in Older Adults With Mild Cognitive Impairment

TypeinterventionalSponsorNational University of SingaporeRan2022 to 2023Enrolled50ConditionsMild Cognitive ImpairmentArmsExperimental: The probiotic drink study group, Placebo Comparator: The placebo drink study group
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  17. Microorganisms · 2024
    Review
  18. Global rural health disparities in Alzheimer's disease and related dementias: State of the science.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Wei Wei Thwe KhineDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
Miao Lian VoongDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
Ted Kheng Siang NgDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Lei FengDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Grishma Avinash RaneDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Alan Prem KumarDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Ee Heok KuaDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Ratha MahendranDepartment of Surgery, National University Hospital, Singapore 119228, Singapore.
Rathi MahendranDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore.
Yuan-Kun LeeDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
National University of Singapore · SGNational University Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is ample scientific and clinical evidence of the effects of gut microbiota on the brain but no definitive evidence that the brain can affect changes in gut microbiota under the bi-directional gut-brain axis concept. As there is no pharmacotherapeutic intervention for the early stages of cognitive decline, research has focused on cognitive stimulation in reversing or slowing the impairment. Elderly patients diagnosed with mild cognitive impairment underwent a randomized-control trial of mindful awareness practice. Neuropsychological assessments, inflammatory markers, and gut microbiota profiles were tested. Here, we report that their cognitive impairment was improved and associated with changes in gut bacterial profile. A cognition-score-dependent-abundance was observed in

Indexed as

CognitionGastrointestinal MicrobiomeMindfulnessAgedAged, 80 and overAge FactorsBrainCognitive DysfunctionFecesFemaleHumansIntestinesMaleMiddle AgedSingaporeTime Factorsgut-brain axismental healthmicrobiomemild cognitive impairmentmindful awareness practice

Identifiers

PMID33318317
PMCPMC7762482
OpenAlexW3110792459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.