ArticleProceedings of the National Academy of Sciences of the United States of America2020
Heterozygous germline
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Epidemiological and Prognostic Differences in Malignant Mesothelioma Between Eastern China and SEER Database.Cancer science · 2026Article
- Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.Cell genomics · 2026Article
- Carrier screening in the reproductive setting-Are there medical implications for the heterozygote?-A guide for clinicians.Pregnancy (Hoboken, N.J.) · 2026Review
- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- The genetics of cancer heterogeneity and mesothelioma.Frontiers in oncology · 2026Review
- Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025Article
- Germline Cancer Susceptibility Variants in Patients With Uveal Melanoma.Pigment cell & melanoma research · 2025Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Pathogenic Germline Variants in Uveal Melanoma Driver and BAP1-Associated Genes in Finnish Patients with Uveal Melanoma.Pigment cell & melanoma research · 2025Article
- Increased frequency of clonal hematopoiesis of indeterminate potential in Bloom syndrome probands and carriers.Haematologica · 2025Article
- Burden of malignant mesothelioma in China during 1990-2019 and the projections through 2029.Journal of the National Cancer Center · 2024Article
- GermlineProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gene-environment interactions within a precision environmental health framework.Cell genomics · 2024Review
- Article
- BLM mutation is associated with increased tumor mutation burden and improved survival after immunotherapy across multiple cancers.Cancer medicine · 2024Article
- Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma.Journal of translational medicine · 2023Review
- HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- BAP1 is a novel regulator of HIF-1α.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.Frontiers in oncology · 2023Review
- Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 9 institutions in 3 countries.
Angela BononiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Keisuke GotoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Guntulu AkLung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.ORCID 0000-0001-8849-193X
Yoshie YoshikawaDepartment of Genetics, Hyogo College of Medicine, Hyogo, 663-8501, Japan.ORCID 0000-0003-0619-0784
Mitsuru EmiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Sandra PastorinoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.ORCID 0000-0002-4559-1065
Lorenzo CarparelliThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Angelica FerroThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Masaki NasuThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Jin-Hee KimThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Joelle S SuarezThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.ORCID 0000-0003-1528-2701
Ronghui XuThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.ORCID 0000-0002-9842-2628
Mika TanjiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Yasutaka TakinishiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Michael MinaaiThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.
Flavia NovelliThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.ORCID 0000-0002-3746-7478
Ian PaganoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.ORCID 0000-0002-6248-0113
Giovanni GaudinoThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813.ORCID 0000-0002-1572-6571
Harvey I PassDepartment of Cardiovascular Surgery, New York University, New York, NY 10016.ORCID 0000-0003-3222-3471
Joanna GrodenVC Research, University of Illinois, Chicago, IL 60607.
Joseph J GrzymskiCenter for Genomic Medicine, Desert Research Institute and Renown Health, Reno, NV 89512.ORCID 0000-0003-2646-8958
Muzaffer MetintasLung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey.
Muhittin AkarsuDepartment of Chest Disease, Eskisehir City Hospital, Eskisehir 26080, Turkey.
Betsy MorrowThoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.ORCID 0000-0001-7112-1078
Raffit HassanThoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Haining YangThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813; haining@hawaii.edu mcarbone@cc.hawaii.edu.ORCID 0000-0003-1417-2420
Michele CarboneThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813; haining@hawaii.edu mcarbone@cc.hawaii.edu.ORCID 0000-0001-8928-8474
University of Hawaiʻi at Mānoa · USEskişehir Osmangazi University · TRNational Cancer Institute · USEskişehir City Hospital · TRHiroshima University · JPHyogo Medical University · JPNew York University · USRenown Health · USUniversity of Illinois Urbana-Champaign · US
Funding
UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MThe EDRN Mesothelioma Biomarker Discovery LaboratoryU01CA214195 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PASS, HARVEY IRA, YANG, HAINING · 2016 to 2021
$3.5MInfluence of germline mutations on susceptibility to environmental carcinogensR01ES030948 · NIEHS · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE, GRZYMSKI, JOSEPH J · 2019 to 2021
$1.9MGermline BAP1 Mutations and Malignant Mesothelioma: Mechanisms and Early DetectionR01CA198138 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CARBONE, MICHELE · 2015 to 2019
$1.7MImmunotherapy for Malignant MesotheliomaZ01BC010816 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HASSAN, RAFFIT · 2007 to 2008
$1.3MIntramural NIH HHS Z01 BC010816NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA198138NCI NIH HHS U01 CA214195NIEHS NIH HHS R01 ES030948NIGMS NIH HHS P20 GM103466
Abstract
Rare biallelic
Indexed as
Genetic Predisposition to DiseaseAdultAgedAnimalsAsbestos, CrocidoliteAsbestosisFamilyFemaleGenomic InstabilityGerm-Line MutationHeterozygoteHumansIncidenceInflammationMaleMesotheliomaAsbestos, CrocidoliteBloom syndrome proteinRecQ HelicasesasbestosBLMgene–environmentgeneticsmesothelioma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.