ArticleProceedings of the National Academy of Sciences of the United States of America2020
Actin-ring segment switching drives nonadhesive gap closure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Microscale matrix defects suppress tension-dependent protrusions and stall collective cell migration.Cell reports · 2026Article
- Partial epithelial-to-mesenchymal transition mediates profound gap closure through growth and fluidization.bioRxiv : the preprint server for biology · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Myoblast Choreographic Alignment.ACS nano · 2025Article
- Large Polyacrylamide Hydrogels for Large-Batch Cell Culture and Mechanobiological Studies.Macromolecular bioscience · 2023Article
- Article
- Morphological transformations of vesicles with confined flexible filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Geometry-mediated bridging drives nonadhesive stripe wound healing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Size-dependent response of cells in epithelial tissue modulated by contractile stress fibers.Biophysical journal · 2023Article
- Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Active chemo-mechanical feedbacks dictate the collective migration of cells on patterned surfaces.Biophysical journal · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Gap closure to eliminate physical discontinuities and restore tissue integrity is a fundamental process in normal development and repair of damaged tissues and organs. Here, we demonstrate a nonadhesive gap closure model in which collective cell migration, large-scale actin-network fusion, and purse-string contraction orchestrate to restore the gap. Proliferative pressure drives migrating cells to attach onto the gap front at which a pluricellular actin ring is already assembled. An actin-ring segment switching process then occurs by fusion of actin fibers from the newly attached cells into the actin cable and defusion from the previously lined cells, thereby narrowing the gap. Such actin-cable segment switching occurs favorably at high curvature edges of the gap, yielding size-dependent gap closure. Cellular force microscopies evidence that a persistent rise in the radial component of inward traction force signifies successful actin-cable segment switching. A kinetic model that integrates cell proliferation, actin fiber fusion, and purse-string contraction is formulated to quantitatively account for the gap-closure dynamics. Our data reveal a previously unexplored mechanism in which cells exploit multifaceted strategies in a highly cooperative manner to close nonadhesive gaps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.