Evidence map›Paper›PMID 33318192›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin.

Hui Liu, Yan Zhang, You-You Zhang, Yan-Ping Li, Zi-Qi Hua, Chang-Jun Zhang, Kun-Chao Wu, Fulong Yu, Yaru Zhang, Jianzhong Su and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.

  1. Pooled it
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  11. Article
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  15. Article
  16. ElevatedCancer genomics & proteomics · 2025
    Article
  17. Retinoma: An overview.Pediatric investigation · 2025
    Review
  18. Proteogenomic discovery ofScience advances · 2025
    Article
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hui LiuLaboratory of Stem Cell and Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0003-0444-5579
Yan ZhangInstitute of Biomedical Big Data, School of Biomedical Engineering, School of Ophthalmology and Optometry, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0002-1011-6184
You-You ZhangLaboratory of Stem Cell and Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0003-0493-847X
Yan-Ping LiLaboratory of Stem Cell and Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0002-0084-3652
Zi-Qi HuaLaboratory of Stem Cell and Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0002-4217-504X
Chang-Jun ZhangBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 100730 Beijing, China.ORCID 0000-0002-8846-6408
Kun-Chao WuLaboratory of Stem Cell and Retinal Regeneration, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0002-8392-8482
Fulong YuInstitute of Biomedical Big Data, School of Biomedical Engineering, School of Ophthalmology and Optometry, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0002-6100-8300
Yaru ZhangInstitute of Biomedical Big Data, School of Biomedical Engineering, School of Ophthalmology and Optometry, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China.ORCID 0000-0002-6167-7248
Jianzhong SuInstitute of Biomedical Big Data, School of Biomedical Engineering, School of Ophthalmology and Optometry, The Eye Hospital, Wenzhou Medical University, 325027 Wenzhou, China; sujz@wmu.edu.cn jinzibing@foxmail.com.ORCID 0000-0003-1054-6042
Zi-Bing JinBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 100730 Beijing, China; sujz@wmu.edu.cn jinzibing@foxmail.com.ORCID 0000-0003-0515-698X
Wenzhou Medical University · CNBeijing Tongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoblastoma (Rb) is the most prevalent intraocular malignancy in children, with a worldwide survival rate <30%. We have developed a cancerous model of Rb in retinal organoids derived from genetically engineered human embryonic stem cells (hESCs) with a biallelic mutagenesis of the

Indexed as

Amino Acid SequenceAnimalsBase SequenceCarcinogenesisHuman Embryonic Stem CellsHumansMice, Inbred NODMutagenesisMutationOrganoidsRetinoblastomaRetinoblastoma ProteinTranscriptomeRetinoblastoma Proteincell of originhuman embryonic stem cellsRB1retinal organoidsretinoblastoma

Identifiers

PMID33318192
PMCPMC7776986
OpenAlexW3112275988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.