ArticleProceedings of the National Academy of Sciences of the United States of America2020
Uncovering the genetic blueprint of the
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Nematode extracellular protein interactome expands connections between signaling pathways.Cell genomics · 2026Article
- A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The structural grammar of integration and competition in the human connectome.Frontiers in computational neuroscience · 2026Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Sparse connectivity enables efficient information processing in cortex-like artificial neural networks.Frontiers in neural circuits · 2025Article
- Combined topological and spatial constraints are required to capture the structure of neural connectomes.Network neuroscience (Cambridge, Mass.) · 2025Article
- Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways.bioRxiv : the preprint server for biology · 2024Article
- Article
- Proper network randomization is key to assessing social balance.Science advances · 2024Article
- Functional neuronal circuits emerge in the absence of developmental activity.Nature communications · 2024Article
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Neuroscience Needs Network Science.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuronal wiring diagram of an adult brain.bioRxiv : the preprint server for biology · 2023Article
- A positive statistical benchmark to assess network agreement.Nature communications · 2023Article
- Neuroscience needs Network Science.ArXiv · 2023Article
- Complex computation from developmental priors.Nature communications · 2023Article
- Feature learning and network structure from noisy node activity data.Physical review. E · 2022Article
- An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research.Cells · 2022Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Despite rapid advances in connectome mapping and neuronal genetics, we lack theoretical and computational tools to unveil, in an experimentally testable fashion, the genetic mechanisms that govern neuronal wiring. Here we introduce a computational framework to link the adjacency matrix of a connectome to the expression patterns of its neurons, helping us uncover a set of genetic rules that govern the interactions between neurons in contact. The method incorporates the biological realities of the system, accounting for noise from data collection limitations, as well as spatial restrictions. The resulting methodology allows us to infer a network of 19 innexin interactions that govern the formation of gap junctions in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.