Evidence map›Paper›PMID 33318128›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Binding of cardiotonic steroids to Na

Ryuta Kanai, Flemming Cornelius, Haruo Ogawa, Kanna Motoyama, Bente Vilsen, Chikashi Toyoshima

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Inhibition of NaBiomedical engineering online · 2025
    Article
  8. Article
  9. Multistate Kinetic Model of the Sodium-Potassium ATPase.The journal of physical chemistry. B · 2025
    Article
  10. How palytoxin transforms the NaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Evolutionary insights into NaBMC ecology and evolution · 2025
    Article
  13. Review
  14. An animal-type NaFrontiers in plant science · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. NaInternational journal of molecular sciences · 2024
    Review
  19. Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ryuta KanaiInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan.ORCID 0000-0002-9213-5193
Flemming CorneliusDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0003-1566-0020
Haruo OgawaInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan.ORCID 0000-0001-5515-1533
Kanna MotoyamaInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan.
Bente VilsenDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-4727-9382
Chikashi ToyoshimaInstitute for Quantitative Biosciences, The University of Tokyo, 113-0032 Tokyo, Japan; ct@iqb.u-tokyo.ac.jp.ORCID 0000-0001-9640-0778
The University of Tokyo · JPAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sodium pump (Na

Indexed as

AnimalsBiophysical PhenomenaCardiac GlycosidesDigoxinModels, MolecularMolecular ConformationOuabainProtein IsoformsSodiumSodium-Potassium-Exchanging ATPaseCardiac GlycosidesDigoxinOuabainProtein IsoformsSodiumSodium-Potassium-Exchanging ATPasecardiotonic steroidscrystal structuresisoform specificityNa+,K+-ATPasesodium pump

Identifiers

PMID33318128
PMCPMC7817145
OpenAlexW3112687479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.