Evidence map›Paper›PMID 33318080›Full record

ArticleLife science alliance2021

Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in

Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison, Margaux Sica, Ashish Jain, Kevin G Moffat, Terje Johansen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Autophagy and the hallmarks of aging.Ageing research reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Anne-Claire JacominSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID 0000-0001-8761-1514
Raksha GohelSchool of Life Sciences, University of Warwick, Coventry, UK.
Zunoon HussainSchool of Life Sciences, University of Warwick, Coventry, UK.
Agnes VargaDepartment of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary.ORCID 0000-0002-2120-1499
Tamas MaruzsInstitute of Genetics, Biological Research Centre, Szeged, Hungary.
Mark EddisonDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Margaux SicaDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Ashish JainMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0001-6549-2788
Kevin G MoffatSchool of Life Sciences, University of Warwick, Coventry, UK.
Terje JohansenMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-1451-9578
Andreas JennyDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-5989-8212
Gabor JuhaszDepartment of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary.ORCID 0000-0001-8548-8874
Ioannis P NezisSchool of Life Sciences, University of Warwick, Coventry, UK I.Nezis@warwick.ac.uk.ORCID 0000-0003-0233-7574
University of Warwick · GBAlbert Einstein College of Medicine · USEötvös Loránd University · HUHUN-REN Szegedi Biológiai Kutatóközpont · HUOslo University Hospital · NOUiT The Arctic University of Norway · NOUniversity of California, San Francisco · US

Funding

ENDOSOMAL MICROAUTOPHAGY IN DROSOPHILAR01GM119160 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JENNY, ANDREAS · 2017 to 2025
$3.9M
NIGMS NIH HHS R01 GM119160
6 · The paper itself

Abstract

Hunger drives food-seeking behaviour and controls adaptation of organisms to nutrient availability and energy stores. Lipids constitute an essential source of energy in the cell that can be mobilised during fasting by autophagy. Selective degradation of proteins by autophagy is made possible essentially by the presence of LIR and KFERQ-like motifs. Using in silico screening of

Indexed as

Adaptation, PhysiologicalMicroautophagyStarvationAnimalsChromatography, LiquidDrosophilaDrosophila ProteinsEndosomesInsulinLipid MetabolismNutrientsProteomeProteomicsTandem Mass SpectrometryTOR Serine-Threonine KinasesDrosophila ProteinsInsulinNutrientsProteomeTOR Serine-Threonine Kinases

Identifiers

PMID33318080
PMCPMC7756965
OpenAlexW3109389628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.