Evidence map›Paper›PMID 33318001›Full record

ArticleAntimicrobial agents and chemotherapy2021

Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant

Yongliang Fang, Jack R Kirsch, Liang Li, Seth A Brooks, Spencer Heim, Cynthia Tan, Susan Eszterhas, Hao D Cheng, Hongliang Zhao, Yan Q Xiong and 1 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yongliang FangThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Jack R KirschThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Liang LiThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Seth A BrooksThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Spencer HeimThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Cynthia TanThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Susan EszterhasThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Hao D ChengLyticon LLC, Lebanon, New Hampshire, USA.
Hongliang ZhaoThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Yan Q XiongThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Karl E GriswoldThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA karl.e.griswold@dartmouth.edu.ORCID 0000-0002-9835-3394
Dartmouth College · USUCLA Medical Center · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Design and Development of Immunotolerant S. aureus BiotherapiesR42AI118133 · NIAID · LYTICON, LLC · PI BAILEY-KELLOGG, CHRIS, GRISWOLD, KARL E · 2017 to 2018
$1.5M
Design and Development of Immunotolerant S. aureus BiotherapiesR41AI118133 · NIAID · STEALTH BIOLOGICS, LLC · PI BAILEY-KELLOGG, CHRIS · 2015 to 2015
$186k
NCI NIH HHS P30 CA023108NIAID NIH HHS R41 AI118133NIAID NIH HHS R42 AI118133NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

There is an urgent need for novel agents to treat drug-resistant bacterial infections, such as multidrug-resistant

Indexed as

Methicillin-Resistant Staphylococcus aureusAnti-Bacterial Agentsbeta-LactamsDrug SynergismHumansLysostaphinMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial Agentsbeta-LactamsLysostaphinantibiotic resistancebeta-lactamsbiotherapeuticinfective endocarditislysinlysostaphinMRSAStaphylococcus aureussynergismsynergy

Identifiers

PMID33318001
PMCPMC8092544
OpenAlexW3111749708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.