Evidence map›Paper›PMID 33317918›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2021

Late-Onset Suicide: A Dementia Prodrome?

Swathi Gujral, Meryl A Butters, Alexandre Y Dombrovski, Katalin Szanto

Abstract read
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Review
  3. Personality Profiles of Older Suicide Attempters: Cross-Sectional And Prospective Differences From Depressed Nonattempter And Nonpsychiatric Comparisons.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
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  9. Is Late-Onset Suicidal Behavior a Distinct Subtype?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Review
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  14. Review
  15. The Role of Perceived and Objective Social Connectedness on Risk for Suicidal Thoughts and Behavior in Late-Life and Their Moderating Effect on Cognitive Deficits.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Article
  16. Article
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  19. Improving Social Connections to Reduce Suicide Risk: A Promising Intervention Target?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Swathi GujralVA VISN 4 Mental Illness Research, Education, and Clinical Center of Excellence (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA. Electronic address: swathi.gujral@va.gov.
Meryl A ButtersUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA.
Alexandre Y DombrovskiUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA.
Katalin SzantoUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA.

Funding

PSYCHOBIOLOGY OF SUICIDAL BEHAVIOR IN BPDR01MH048463 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Alexandre Y. Dombrovski · 1992 to 2026
$13.9M
Short Term Variability in Affect and Rest Activity Rhythms in Long Term Chronic and Highly Variable Suicidal Ideation in Depressed Older AdultsR01MH085651 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANGA CSILLA GALFALVY, Swathi Gujral · 2010 to 2026
$9.6M
Reward Learning in Late-Life Suicidal BehaviorR01MH100095 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Alexandre Y. Dombrovski · 2014 to 2026
$6.8M
3/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depressionR01MH114969 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2017 to 2021
$2.6M
Aerobic Exercise for Optimizing Cognitive and Brain Health In Remitted Late-Life DepressionK23MH125074 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GUJRAL, SWATHI · 2021 to 2025
$828k
NIMH NIH HHS K23 MH125074NIMH NIH HHS R01 MH048463NIMH NIH HHS R01 MH085651NIMH NIH HHS R01 MH100095NIMH NIH HHS R01 MH114969
6 · The paper itself

Abstract

objectivesThis study examined whether late-onset (versus early-onset) suicidal behavior is associated with worse cognition.

methodsParticipants included 278 adults aged 50+ years (56 nonpsychiatric comparison group; 67 nonsuicidal depressed older adults; 63 depressed suicide ideators; and 44 late-onset (55+ years) and 48 early-onset suicide attempters (<55 years). Using a case-control design, this study examined group differences in global cognition, episodic memory, information processing speed, and executive functioning, assessed using the Repeatable Battery of Neuropsychological Status and the Trail Making Test from the Delis-Kaplan Executive Function System. Linear regression was used for data analyses.

resultsBoth attempter groups displayed worse executive functioning than nonsuicidal depressed older adults. Late-onset attempters additionally displayed poorer global cognition and processing speed than nonsuicidal depressed older adults and poorer memory than early-onset attempters.

conclusionsLate-onset suicidal behavior is associated with worse performance in a broad range of cognitive domains, possibly reflective of a dementia prodrome.

Indexed as

DementiaSuicideAgedExecutive FunctionHumansNeuropsychological TestsSuicidal IdeationSuicide, AttemptedCognitionDementiaLate-life depressionSuicide

Identifiers

PMID33317918
PMCPMC8187470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.