Evidence map›Paper›PMID 33317591›Full record

ArticleJournal of experimental & clinical cancer research : CR2020

BRAF

Nadia Trivieri, Riccardo Pracella, Maria Grazia Cariglia, Concetta Panebianco, Paola Parrella, Alberto Visioli, Fabrizio Giani, Amata Amy Soriano, Chiara Barile, Giuseppe Canistro and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  16. Genetic heterogeneity of colorectal cancer and the microbiome.World journal of gastrointestinal oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Nadia TrivieriCancer Stem Cells Unit, ISBReMIT, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Riccardo PracellaCancer Stem Cells Unit, ISBReMIT, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Maria Grazia CarigliaCancer Stem Cells Unit, ISBReMIT, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Concetta PanebiancoGastroenterology Unit, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Paola ParrellaOncology Laboratory, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Alberto VisioliStemGen SpA, Milan, Italy.
Fabrizio GianiStemGen SpA, Milan, Italy.
Amata Amy SorianoCancer Stem Cells Unit, ISBReMIT, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Chiara BarileCancer Stem Cells Unit, ISBReMIT, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Giuseppe CanistroAbdominal Surgery Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
Tiziana Pia LatianoDivision of Medical Oncology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
Lucia DimitriAnatomical Pathology Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
Francesca BazzocchiAbdominal Surgery Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
Dario CassanoAbdominal Surgery Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
Angelo L VescoviStemGen SpA, Milan, Italy.
Valerio PazienzaGastroenterology Unit, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy.
Elena BindaCancer Stem Cells Unit, ISBReMIT, IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, FG, Italy. e.binda@operapadrepio.it.ORCID http://orcid.org/0000-0002-8750-2905
Casa Sollievo della Sofferenza · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG2018-ID22027Associazione Italiana per la Ricerca sul Cancro IG2019-ID23006Ministero della Salute GR-2011-02351534Ministero della Salute Progetto Ricerca Corrente 2018-20
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) harboring BRAF

methodsBy injecting human CRC stem-like cells isolated from BRAF

resultsA specific microbial signature distinctive for BRAF status emerged, being the BRAF-mutated cases closer to healthy controls than BRAF wild-type counterpart. In agreement, a considerable score of correlation was also pointed out between bacteria abundance from BRAF-mutated cases and the level of markers distinctive of BRAF

conclusionOverall, our results suggest that BRAF

Indexed as

Gastrointestinal MicrobiomeMutationAgedAged, 80 and overAnimalsApoptosisBiomarkers, TumorCell ProliferationColorectal NeoplasmsFecesFemaleHumansMaleMiceMice, SCIDMiddle AgedBiomarkers, TumorBRAF protein, humanProto-Oncogene Proteins B-rafAnti-BRAF V600E CRC patient-tailored strategiesBRAF V600E CRC non-invasive diagnosisCRC biology and biomarkersGut microbiotaSerrated human BRAF V600E colorectal carcinoma (CRC)

Identifiers

PMID33317591
PMCPMC7737386
OpenAlexW3111086695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.