Evidence map›Paper›PMID 33317579›Full record

Trial reportCritical care (London, England)2020

High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial.

Andrea Cortegiani, Federico Longhini, Fabiana Madotto, Paolo Groff, Raffaele Scala, Claudia Crimi, Annalisa Carlucci, Andrea Bruni, Eugenio Garofalo, Santi Maurizio Raineri and 10 more

4 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 71 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 15 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03370666 nacompletednot on this map

High Flow Nasal Therapy Versus Noninvasive Ventilation in Mild to Moderate Acute Hypercapnic Respiratory Failure: A Non-inferiority Randomized Trial

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Policlinico Paolo Giaccone PalermoRan2018 to 2020Enrolled80ConditionsCOPD ExacerbationArmsHFNT, NIV
NCT06204276 nacompletednot on this mapstarted 2024, after this paper: background citation

The Physiologic Effects of Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure. A Randomized Crossover Study.

TypeinterventionalSponsorSiriraj HospitalRan2024 to 2024Enrolled40ConditionsAcute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory FailureArmsExperimental: Asymmetrical high-flow nasal cannula, Active comparator: Conventional high-flow nasal cannula
NCT06257667 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Randomized Controlled Trial to Investigate the Effect of High Flow Nasal Cannula Treatment on Carbon Dioxide-levels in COPD- Patients With Acute Hypercapnic Respiratory Failure, Using Either OptiflowTM or Optiflow+DuetTM Nasal Cannula

TypeinterventionalSponsorAalborg University HospitalRan2024 to 2026Enrolled138ConditionsHypercapnic Respiratory Failure, COPDArmsRespiratory Support
NCT06495086 nacompletednot on this mapstarted 2023, after this paper: background citation

A High-Flow Nasal Cannula Versus Noninvasive Ventilation in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Single-blind Randomized Trial

TypeinterventionalSponsorHaseki Training and Research HospitalRan2023 to 2024Enrolled137ConditionsCOPD Exacerbations, Acute Hypercapnic Respiratory Failure, Respiratory FailureArmsNIV, HFNC-30, HFNC-50
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 15 syntheses or guidelines pooled it, 120 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 1 country.

Andrea CortegianiDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy. andrea.cortegiani@unipa.it.ORCID 0000-0003-1416-9993
Federico LonghiniIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Fabiana MadottoValue-Based Healthcare Unit, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.
Paolo GroffEmergency Department, "S. Maria Della Misericordia" Hospital, Perugia, Italy.
Raffaele ScalaPulmonology and Respiratory Intensive Care Unit, S. Donato Hospital, Arezzo, Italy.
Claudia CrimiRespiratory Medicine Unit, A.O.U. "Policlinico-Vittorio Emanuele", Catania, Italy.
Annalisa CarlucciPulmonary Rehabilitation Unit, Department of Medicina E Chirurgia, Istituti Clinici Scientifici Maugeri, Università Insubria Varese, Pavia, Italy.
Andrea BruniIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Eugenio GarofaloIntensive Care Unit, Department of Medical and Surgical Sciences, University Hospital Mater Domini, Magna Graecia University, Catanzaro, Italy.
Santi Maurizio RaineriDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy.
Roberto TonelliClinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
Vittoria ComelliniDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Enrico LupiaUnit of Emergency Medicine, Department of Medical Sciences, University of Turin, Turin, Italy.
Luigi VetrugnoDepartment of Medicine, Clinic of Anesthesia and Intensive Care, University of Udine, Udine, Italy.
Enrico CliniRespiratory Diseases Unit, Department of Medical and Surgical Sciences SMECHIMAI, University Hospital of Modena Policlinico, University of Modena Reggio Emilia, Modena, Italy.
Antonino GiarratanoDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy.
Stefano NavaDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Paolo NavalesiSection of Anesthesiology and Intensive Care, Department of Medicine - DIMED, University of Padova, Padova, Italy.
Cesare GregorettiDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, Palermo, Italy.
H. F.-AECOPD study investigators
Magna Graecia University · ITUniversity of Modena and Reggio Emilia · ITAzienda Ospedaliera di Perugia · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Padua · ITFondazione Istituto G. Giglio di Cefalù · ITIstituti Clinici Scientifici Maugeri · ITOspedale San Donato · ITUniversity of Palermo · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy and safety of high flow nasal therapy (HFNT) in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to evaluate the short-term effect of HFNT versus NIV in patients with mild-to-moderate AECOPD, with the hypothesis that HFNT is non-inferior to NIV on CO

methodsWe performed a multicenter, non-inferiority randomized trial comparing HFNT and noninvasive ventilation (NIV) in nine centers in Italy. Patients were eligible if presented with mild-to-moderate AECOPD (arterial pH 7.25-7.35, PaCO

resultsSeventy-nine patients were analyzed (80 patients randomized). Mean differences for PaCO

conclusionsHFNT was statistically non-inferior to NIV as initial ventilatory support in decreasing PaCO

trial registrationThe study was prospectively registered on December 12, 2017, in ClinicalTrials.gov (NCT03370666).

Indexed as

AgedCannulaEquivalence Trials as TopicFemaleHumansItalyMaleMiddle AgedNoninvasive VentilationOxygen Inhalation TherapyPulmonary Disease, Chronic ObstructiveSymptom Flare UpAcute respiratory failureChronic obstructive pulmonary diseaseHigh flow nasal cannulaHigh flow nasal therapyNoninvasive ventilation

Identifiers

PMID33317579
PMCPMC7734463
OpenAlexW3111623578

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.