Evidence map›Paper›PMID 33317422›Full record

Trial reportNeurorehabilitation and neural repair2021

White Matter Integrity Predicts Electrical Stimulation (tDCS) and Language Therapy Effects in Primary Progressive Aphasia.

Yi Zhao, Bronte Ficek, Kimberly Webster, Constantine Frangakis, Brian Caffo, Argye E Hillis, Andreia Faria, Kyrana Tsapkini

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  8. White Matter Hyperintensities as a Predictor of Aphasia Recovery.Archives of physical medicine and rehabilitation · 2024
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  9. White matter predicts tDCS antidepressant effects in a sham-controlled clinical trial study.European archives of psychiatry and clinical neuroscience · 2023
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  13. Frontiers in neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yi ZhaoDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Bronte FicekDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kimberly WebsterDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Constantine FrangakisDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Brian CaffoDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Argye E HillisDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Andreia FariaDepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kyrana TsapkiniDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6020-5532
Johns Hopkins University · US

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021
$6.4M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
Transcranial direct current stimulation in typical and atypical Alzheimer's diseaseR01AG068881 · NIA · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2020 to 2024
$3.8M
Modafinil Treatment for Cocaine DependenceR01DA015366 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DACKIS, CHARLES · 2004 to 2007
$2.3M
Statistical methods for characterizing patients who highly-benefit from treatments and programs in Alzheimers, HIV, and other heterogeneous diseasesR01AI140854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI FRANGAKIS, CONSTANTINE E · 2018 to 2021
$1.8M
NIAID NIH HHS R01 AI140854NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG068881NIDA NIH HHS R01 DA015366NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC011317NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS), in conjunction with language therapy, improves language therapy outcomes in primary progressive aphasia (PPA). However, no studies show whether white matter integrity predicts language therapy or tDCS effects in PPA.

objectiveWe aimed to determine whether white matter integrity, measured by diffusion tensor imaging (DTI), predicts written naming/spelling language therapy effects (letter accuracy on trained and untrained words) with and without tDCS over the left inferior frontal gyrus (IFG) in PPA.

methodsThirty-nine participants with PPA were randomly assigned to tDCS or sham condition, coupled with language therapy for 15 daily sessions. White matter integrity was measured by mean diffusivity (MD) and fractional anisotropy (FA) in DTI scans before therapy. Written naming outcomes were evaluated before, immediately after, 2 weeks, and 2 months posttherapy. To assess tDCS treatment effect, we used a mixed-effects model with treatment evaluation and time interaction. We considered a forward model selection approach to identify brain regions/fasciculi of which white matter integrity can predict improvement in performance of word naming.

resultsBoth sham and tDCS groups significantly improved in trained items immediately after and at 2 months posttherapy. Improvement in the tDCS group was greater and generalized to untrained words. White matter integrity of ventral language pathways predicted tDCS effects in trained items whereas white matter integrity of dorsal language pathways predicted tDCS effects in untrained items.

conclusionsWhite matter integrity influences both language therapy and tDCS effects. Thus, it holds promise as a biomarker for deciding which patients will benefit from language therapy and tDCS.

Indexed as

Language TherapyOutcome Assessment, Health CareTranscranial Direct Current StimulationAgedAged, 80 and overAphasia, Primary ProgressiveCombined Modality TherapyCross-Over StudiesDiffusion Tensor ImagingDouble-Blind MethodFemaleHumansMaleMiddle AgedPlacebosWhite MatterPlaceboselectrical stimulationlanguage therapyneurodegenerationpredictionprimary progressive aphasia (PPA)transcranial direct current stimulation (tDCS)white matterwhite matter integrity

Identifiers

PMID33317422
PMCPMC7748290
OpenAlexW3111043509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.