ArticleJournal of the American Heart Association2020
End-Organ Function and Exercise Performance in Patients With Fontan Circulation: What Characterizes the High Performers?
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Fontan Patients with a Systemic Left Ventricle Have Greater Exercise Capacity than those with a Systemic Right Ventricle: A Systematic Review and Meta-Analysis.Pediatric cardiology · 2026Pooled it
- Fontan Circulation Associated Organ Abnormalities Beyond the Heart, Lungs, Liver, and Gut: A Systematic Review.Frontiers in cardiovascular medicine · 2022Pooled it
- Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial.Journal of the American Heart Association · 2025Trial
- The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation.The American journal of cardiology · 2024Trial
- Successful medical management of recurrent atrial arrhythmia in a non-eligible Fontan patient to ablation: case report and literature review.Annals of medicine and surgery (2012) · 2026Article
- Lower Child Opportunity Index is Associated with Lower Exercise Capacity Post-Fontan Palliation.Pediatric cardiology · 2026Article
- Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation.Pediatric cardiology · 2025Article
- Circulating Biomarkers in Failing Fontan Circulation: Current Evidence and Future Directions.Journal of cardiovascular development and disease · 2025Review
- Determinants of cardiac output in health and heart failure.Experimental physiology · 2025Review
- Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation.Journal of the American Heart Association · 2025Article
- Hypoplastic left heart syndrome (HLHS) becomes of age: Assessing the young adult with HLHS including the neoaorta/aortic arch.International journal of cardiology. Congenital heart disease · 2025Review
- Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes.Circulation. Heart failure · 2025Article
- Blood Biomarkers as a Non-Invasive Method for the Assessment of the State of the Fontan Circulation.Journal of clinical medicine · 2025Review
- Long-term outcomes of extracardiac Gore-Tex conduits in Fontan patients.International journal of cardiology. Congenital heart disease · 2024Article
- Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model.Pediatric research · 2024Article
- Impact of pulsatile pulmonary blood flow on cardiopulmonary exercise performance after the Fontan procedure.JTCVS open · 2023Article
- Exercise Pathophysiology and Testing in Individuals With a Fontan Circulation.CJC pediatric and congenital heart disease · 2023Review
- Surrogates of Muscle Mass on Cardiac MRI Correlate with Exercise Capacity in Patients with Fontan Circulation.Journal of clinical medicine · 2023Article
- A Path FORWARD: Development of a Comprehensive Multidisciplinary Clinic to Create Health and Wellness for the Child and Adolescent with a Fontan Circulation.Pediatric cardiology · 2022Review
- You can only change what you measure: an argument for more detailed characterization in the Fontan circulation.European heart journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The physiologic hallmarks of the Fontan circulation-chronically elevated central venous pressures and low cardiac output-have significant effects not only on cardiovascular status but also impact other organ systems. Exercise capacity is limited in many and declines with age, accelerating in adolescence, but with wide variability. We explore the relationship between exercise performance and end-organ function in outpatient subjects with a Fontan circulation. Methods and Results This is a cross-sectional analysis of subject end-organ characterization from our outpatient Fontan circulation clinic with peak oxygen consumption (peak Vo
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.