ArticleClinical and molecular hepatology2021
Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients.
Article in Clinical and molecular hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Readmission rates among patients with cirrhosis across different follow-up periods and prevalence of major complications: a systematic review and meta-analysis.Open medicine (Warsaw, Poland) · 2026Article
- Global, regional, and national burdens of alcohol-related cirrhosis among women from 1992 to 2021 and its predictions.Scientific reports · 2025Article
- Machine learning-based nomogram for mortality risk stratification in cirrhotic patients with sepsis: a single-center predictive model.Frontiers in medicine · 2025Article
- Acute kidney injury development is associated with mortality in Japanese patients with cirrhosis: impact of amino acid imbalance.Journal of gastroenterology · 2024Article
- Recent insights into contributing factors in the pathogenesis of cirrhotic ascites.Frontiers in medicine · 2024Review
- Excess mortality in elderly hip fracture patients: An Indian experience.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023Article
- Predictive Factors for the Prognosis of Alcoholic Liver Cirrhosis.Medicina (Kaunas, Lithuania) · 2022Article
- Microbiome-Based Metabolic Therapeutic Approaches in Alcoholic Liver Disease.International journal of molecular sciences · 2022Review
- Alcohol-related cirrhosis: The most challenging etiology of cirrhosis is more burdensome than ever.Clinical and molecular hepatology · 2021Article
- Etiological Spectrum of Cirrhosis in India: A Systematic Review and Meta-analysis.Journal of clinical and experimental hepatologyArticle
- Overview of Complications in Cirrhosis.Journal of clinical and experimental hepatologyReview
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12 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsLiver cirrhosis is an important cause of morbidity and mortality globally. Every episode of decompensation and hospitalization reduces survival. We studied the clinical profile and long-term outcomes comparing alcohol-related cirrhosis (ALC) and non-ALC.
methodsCirrhosis patients at index hospitalisation (from January 2010 to June 2017), with ≥1 year follow-up were included.
resultsFive thousand and one hundred thirty-eight cirrhosis patients (age, 49.8±14.6 years; male, 79.5%; alcohol, 39.5%; Child-A:B:C, 11.7%:41.6%:46.8%) from their index hospitalization were analysed. The median time from diagnosis of cirrhosis to index hospitalization was 2 years (0.2-10). One thousand and seven hundred seven patients (33.2%) died within a year; 1,248 (24.3%) during index hospitalization. 59.5% (2,316/3,890) of the survivors, required at least one readmission, with additional mortality of 19.8% (459/2,316). ALC compared to non-ALC were more often (P<0.001) male (97.7% vs. 67.7%), younger (40-50 group, 36.2% vs. 20.2%; P<0.001) with higher liver related complications at baseline, (P<0.001 for each), sepsis: 20.3% vs. 14.9%; ascites: 82.2% vs. 65.9%; spontaneous bacterial peritonitis: 21.8% vs. 15.7%; hepatic encephalopathy: 41.0% vs. 25.0%; acute variceal bleeding: 32.0% vs. 23.7%; and acute kidney injury 30.5% vs. 19.6%. ALC patients had higher Child-Pugh (10.6±2.0 vs. 9.0±2.3), model for end-stage liver-disease scores (21.49±8.47 vs. 16.85±7.79), and higher mortality (42.3% vs. 27.3%, P<0.001) compared to non-ALC.
conclusionOne-third of cirrhosis patients die in index hospitalization. 60% of the survivors require at least one rehospitalization within a year. ALC patients present with higher morbidity and mortality and at a younger age.
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