Evidence map›Paper›PMID 33317161›Full record

ArticleInternational journal of molecular sciences2020

Association of Soluble Suppression of Tumorigenesis-2 (ST2) with Endothelial Function in Patients with Ischemic Heart Failure.

Stathis Dimitropoulos, Vasiliki Chara Mystakidi, Evangelos Oikonomou, Gerasimos Siasos, Vasiliki Tsigkou, Dimitris Athanasiou, Nikolaos Gouliopoulos, Evanthia Bletsa, Aimilios Kalampogias, Georgios Charalambous and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
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  4. Observational
  5. Myocardial-alternation index (MMI) is correlated with soluble suppression of tumorigenecity-2 (sST2) in patients with ischemic cardiomyopathy.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
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  11. Review
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  17. Differences in maternal soluble ST2 levels in the third trimester of normal pregnancy versus preeclampsia.European journal of obstetrics & gynecology and reproductive biology: X · 2022
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Stathis DimitropoulosFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Vasiliki Chara MystakidiFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-4344-6243
Evangelos OikonomouFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-8079-0599
Gerasimos SiasosFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Vasiliki TsigkouFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Dimitris AthanasiouFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Nikolaos GouliopoulosFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Evanthia BletsaFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0003-3680-859X
Aimilios KalampogiasFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Georgios CharalambousFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Costas TsioufisFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Manolis VavuranakisThird Department of Cardiology, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece.ORCID 0000-0002-5907-4392
Dimitris TousoulisFirst Department of Cardiology, 'Hippokration' General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble suppression of tumorigenesis-2 (sST2) has been introduced as a marker associated with heart failure (HF) pathophysiology and status. Endothelial dysfunction is a component underlying HF pathophysiology. Therefore, we examined the association of arterial wall properties with sST2 levels in patients with HF of ischemic etiology. We enrolled 143 patients with stable HF of ischemic etiology and reduced left ventricular ejection fraction (LVEF) and 77 control subjects. Flow-mediated dilation (FMD) was used to evaluate endothelial function and pulse wave velocity (PWV) to assess arterial stiffness. Although there was no significant difference in baseline demographic characteristics, levels of sST2 were increased in HF compared to the control (15.8 (11.0, 21.8) ng/mL vs. 12.5 (10.4, 16.3) ng/mL;

Indexed as

AgedBiomarkersEndothelium, VascularFemaleHeart FailureHumansInterleukin-1 Receptor-Like 1 ProteinMaleMiddle AgedMyocardial IschemiaPulse Wave AnalysisVascular StiffnessBiomarkersIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 Proteinendothelial functionFMDheart failuresoluble suppression of tumorigenesis-2

Identifiers

PMID33317161
PMCPMC7764062
OpenAlexW3112203670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.