ReviewMolecules (Basel, Switzerland)2020
Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 158 citations in OpenAlex.
- Coordination-controlled photophysics and antiproliferative activity of coumarin-linked schiff bases and Zn(II) complexes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Synthesis and structure of pyridinium tri-chlorido-(pyridine-κActa crystallographica. Section E, Crystallographic communications · 2026Article
- Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole-Resistant Strains of Candida spp. and Cryptococcus neoformans.Chemistry & biodiversity · 2026Article
- Complexes of Zinc(II) Chloride withPharmaceuticals (Basel, Switzerland) · 2026Article
- Anticancer and Antimicrobial Activities of New Cobalt and Zinc Complex-Derived Benzimidazole Containing Nitro or Methyl Groups.ACS omega · 2026Article
- Bis{μ-1,3-bis-[dimeth-yl(pyridin-3-yl)sil-yl]propane-κIUCrData · 2026Article
- Biological effects of p-PYA ligands on certain trace elements of group-12 towards DNA binding and cytotoxicity potency.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Antiproliferative and apoptotic activity of a Zn(II) complex against cancer cells, both in vitro and in vivo.Discover oncology · 2025Article
- Zinc complex with quinoline-based thiazolyl-hydrazone targeting DNA replication in cancer cells.Scientific reports · 2025Article
- Antiproliferative Potential of Cobalt(II) Phenanthroline Complexes with Pyridonates.Molecules (Basel, Switzerland) · 2025Article
- Piperazine-Based Co(III), Ni(II), Cu(II), and Zn(II) Carbodithioate Complexes as Potential Anticancer Agent.ACS omega · 2025Article
- Synthesis, Characterization, and Preliminary In Vitro Anticancer Activity of Zinc Complexes Containing Amino Acid-Derived Imidazolium-Based Dicarboxylate Ligands.International journal of molecular sciences · 2025Article
- Review
- A New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel.Pharmaceutics · 2024Article
- In vitro and in silico studies of a Zn(II) complex as a potential therapeutic agent for breast cancer.Scientific reports · 2024Article
- Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes.Molecules (Basel, Switzerland) · 2024Article
- Synthesis, structural characterization, and theoretical analysis of novel zinc(ii) schiff base complexes with halogen and hydrogen bonding interactions.RSC advances · 2024Article
- Synthesis, kinetics, mechanisms, and bioactivity evaluations of a novel Zn(ii) complex.RSC advances · 2024Article
- Organoselenium transition metal complexes as promising candidates in medicine area.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024Review
- Synthesis, characterization, and crystal structure of hexa-kis-(1-methyl-1Acta crystallographica. Section E, Crystallographic communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The search for anticancer metal-based drugs alternative to platinum derivatives could not exclude zinc derivatives due to the importance of this metal for the correct functioning of the human body. Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, in particular its lack of redox activity and its ability to support different coordination geometries and to promote fast ligands exchange. Analogously to other trace elements, the impairment of its homeostasis can lead to various diseases and in some cases can be also related to cancer development. However, in addition to its physiological role, zinc can have beneficial therapeutic and preventive effects on infectious diseases and, compared to other metal-based drugs, Zn(II) complexes generally exert lower toxicity and offer few side effects. Zinc derivatives have been proposed as antitumor agents and, among the great number of zinc coordination complexes which have been described so far, this review focuses on the design, synthesis and biological studies of zinc complexes comprising N-donor ligands and that have been reported within the last five years.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.