Evidence map›Paper›PMID 33317146›Full record

ReviewJournal of clinical medicine2020

Intraductal Papillary Neoplasm of Bile Duct: Updated Clinicopathological Characteristics and Molecular and Genetic Alterations.

Yasuni Nakanuma, Katsuhiko Uesaka, Yuko Kakuda, Takashi Sugino, Keiichi Kubota, Toru Furukawa, Yuki Fukumura, Hiroyuki Isayama, Takuro Terada

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. European journal of nuclear medicine and molecular imaging · 2026
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  18. [Magnetic resonance imaging features and classification of intraductal papillary neoplasm of the bile duct].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yasuni NakanumaDepartment of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.
Katsuhiko UesakaDepartment of Hepatobiliary Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.
Yuko KakudaDepartment of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.
Takashi SuginoDepartment of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.
Keiichi KubotaDepartment of Hepatobiliary Pancreatic Surgery, Dokkyo University Hospital, Tochigi 321-0293, Japan.
Toru FurukawaDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Yuki FukumuraDeparatment of Human Pathology, Juntendo University School of Medicine, Tokyo 113-8431, Japan.
Hiroyuki IsayamaDepartment of Endoscopy, Juntendo University School of Medicine, Tokyo 113-8431, Japan.
Takuro TeradaDepartment of Gastrointestinal Surgery, Fukui Prefecture Saiseikai Hospital, Fukui 918-8503, Japan.
Shizuoka Cancer Center · JPJuntendo University · JPDokkyo University · JPFukui-ken Saiseikai Hospital · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraductal papillary neoplasm of the bile duct (IPNB), a pre-invasive neoplasm of the bile duct, is being established pathologically as a precursor lesion of invasive cholangiocarcinoma (CCA), and at the time of surgical resection, approximately half of IPNBs show stromal invasion (IPNB associated with invasive carcinoma). IPNB can involve any part of the biliary tree. IPNB shows grossly visible, exophytic growth in a dilated bile duct lumen, with histologically villous/papillary neoplastic epithelia with tubular components covering fine fibrovascular stalks. Interestingly, IPNB can be classified into four subtypes (intestinal, gastric, pancreatobiliary and oncocytic), similar to intraductal papillary mucinous neoplasm of the pancreas (IPMN). IPNBs are classified into low-grade and high-grade based on lining epithelial features. The new subclassification of IPNB into types 1 (low-grade dysplasia and high-grade dysplasia with regular architecture) and 2 (high-grade dysplasia with irregular architecture) proposed by the Japan-Korea pathologist group may be useful in the clinical field. The outcome of post-operative IPNBs is more favorable in type 1 than type 2. Recent genetic studies using next-generation sequencing have demonstrated the existence of several groups of mutations of genes: (i) IPNB showing mutations in

Indexed as

biliary treecholangiocarcinomaintraductal papillary mucinous neoplasm of pancreasintraductal papillary neoplasm of bile ductpreinvasive lesion

Identifiers

PMID33317146
PMCPMC7763595
OpenAlexW3113240453

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.