Evidence map›Paper›PMID 33317138›Full record

ArticleInternational journal of molecular sciences2020

Relation of α

Berthold Hoppe, Christian Schwedler, Hildrun Haibel, Maryna Verba, Fabian Proft, Mikhail Protopopov, Hans-Gert Heuft, Valeria Rios Rodriguez, Anke Edelmann, Martin Rudwaleit and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Berthold HoppeInstitute of Laboratory Medicine, Unfallkrankenhaus Berlin, 12683 Berlin, Germany.ORCID 0000-0002-0784-4017
Christian SchwedlerInstitute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.ORCID 0000-0002-2663-5608
Hildrun HaibelDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.
Maryna VerbaDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.
Fabian ProftDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.ORCID 0000-0003-4306-033X
Mikhail ProtopopovDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.ORCID 0000-0003-4840-5069
Hans-Gert HeuftInstitute of Transfusion Medicine, Otto-von-Guericke Universität Magdeburg, 39120 Magdeburg, Germany.
Valeria Rios RodriguezDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.ORCID 0000-0001-5612-043X
Anke EdelmannDepartment of Molecular Diagnostics, Labor Berlin-Charité Vivantes GmbH, 13353 Berlin, Germany.
Martin RudwaleitDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.
Joachim SieperDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.
Denis PoddubnyyDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany.ORCID 0000-0002-4537-6015
Charité - Universitätsmedizin Berlin · DEHumboldt-Universität zu Berlin · DEGerman Rheumatism Research Centre · DEKlinikum Bielefeld · DEOtto-von-Guericke-Universität Magdeburg · DE

Funding

Bundesministerium für Bildung und Forschung ArthroMark 01EC1009ABundesministerium für Bildung und Forschung ArthroMark II 01EC1401A
6 · The paper itself

Abstract

objectiveCoagulation and fibrinolysis are interrelated with the expression of vascular endothelial growth factor (VEGF), which frequently is increased in axial spondyloarthritis (axSpA). We tested whether (i) α

methodsOne hundred and eighty-six axSpA patients from the German Spondyloarthritis Inception Cohort were genotyped, characterized for VEGF levels, and statistically analyzed. The association between VEGF and radiographic spinal progression was assessed in dependence on genetic background in stratified analyses.

resultsA2AP 6Trp carriage was associated with VEGF elevation (OR: 2.37, 95% CI: 1.06-5.29) and VEGF levels (6Trp, 455 ± 334 pg/mL; 6Arg/Arg, 373 ± 293 pg/mL;

conclusionsThe A2AP Arg6Trp genotype seems to influence VEGF levels in axSpA. The predictive value of VEGF elevations in respect of radiographic spinal progression in axSpA depends on FGA genotypes.

Indexed as

GenotypeAdultalpha-2-AntiplasminFactor VIIIFemaleFibrinogenHumansMaleMiddle AgedSpondylitis, AnkylosingVascular Endothelial Growth Factor Aalpha-2-AntiplasminFactor VIIIFibrinogenVascular Endothelial Growth Factor Afactor XIIIfibrinogenfibrinolysisspondyloarthritisvascular endothelial growth factorα2-antiplasmin

Identifiers

PMID33317138
PMCPMC7764219
OpenAlexW3111710295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.