Evidence map›Paper›PMID 33317091›Full record

ArticleNutrients2020

Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.

Laura Airaksinen, Pilvi Laurikka, Heini Huhtala, Kalle Kurppa, Teea Salmi, Päivi Saavalainen, Katri Kaukinen, Katri Lindfors

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura AiraksinenCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Pilvi LaurikkaCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Heini HuhtalaFaculty of Social Sciences, Tampere University, 33520 Tampere, Finland.
Kalle KurppaTampere Centre for Child Health Research, Tampere University Hospital and Tampere University, 33521 Tampere, Finland.ORCID 0000-0003-4757-2164
Teea SalmiCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Päivi SaavalainenResearch Programs Unit, Immunobiology, and Haartman Institute, Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland.
Katri KaukinenCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Katri LindforsCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.ORCID 0000-0001-7417-5151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical phenotype of celiac disease varies considerably among patients and the dosage of HLA-DQ2.5 alleles has been suggested to be a contributing factor. We investigated whether HLA-DQ2.5 allele dosage is associated with distinct clinical parameters at the time of diagnosis and with patients' response to a gluten-free diet. The final cohort included 605 carefully phenotyped non-related Finnish celiac disease patients grouped as having 0, 1 or 2 copies of HLA-DQ2.5. Clinical data at the time of diagnosis and during gluten-free diet were collected systematically from medical records and supplementary interviews. An increasing HLA-DQ2.5 dose effect was detected for celiac disease antibody positivity at diagnosis (

Indexed as

AdolescentAdultAgedAllelesCeliac DiseaseChildChild, PreschoolCohort StudiesDiet, Gluten-FreeFemaleFinlandFollow-Up StudiesHLA-DQ AntigensHumansInfantMaleHLA-DQ2 antigenHLA-DQ Antigensceliac diseaseclinical presentationdose effectgluten-free dietHLA-DQ2.5

Identifiers

PMID33317091
PMCPMC7764246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.