Evidence map›Paper›PMID 33316896›Full record

ArticleInternational journal of molecular sciences2020

UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex.

Pellegrino Mazzone, Michele Congestrì, Ivan Scudiero, Immacolata Polvere, Serena Voccola, Lucrezia Zerillo, Gianluca Telesio, Pasquale Vito, Romania Stilo, Tiziana Zotti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Novel Ophthalmic Solution Containing GlicoproJournal of clinical medicine · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pellegrino MazzoneBiogem Consortium, Via Camporeale, 83031 Ariano Irpino (AV), Italy.
Michele CongestrìDipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
Ivan ScudieroBiogem Consortium, Via Camporeale, 83031 Ariano Irpino (AV), Italy.
Immacolata PolvereDipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
Serena VoccolaGenus Biotech, Università degli Studi del Sannio, Via Appia snc, 82030 Apollosa (BN), Italy.
Lucrezia ZerilloGenus Biotech, Università degli Studi del Sannio, Via Appia snc, 82030 Apollosa (BN), Italy.
Gianluca TelesioBiogem Consortium, Via Camporeale, 83031 Ariano Irpino (AV), Italy.
Pasquale VitoDipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
Romania StiloDipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.
Tiziana ZottiDipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy.ORCID 0000-0003-4753-116X
University of Sannio · ITBiogem · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CARD14/CARMA2 is a scaffold molecule whose genetic alterations are linked to human inherited inflammatory skin disorders. However, the mechanisms through which CARD14/CARMA2 controls innate immune response and chronic inflammation are not well understood. By means of a yeast two-hybrid screening, we identified the UBA Domain Containing 1 (UBAC1), the non-catalytic subunit of the E3 ubiquitin-protein ligase KPC complex, as an interactor of CARMA2

Indexed as

Adaptor Proteins, Signal TransducingCARD Signaling Adaptor ProteinsGuanylate CyclaseHaCaT CellsHEK293 CellsHumansMembrane ProteinsNF-kappa BProtein BindingSignal TransductionToll-Like Receptor 3UbiquitinationUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseMembrane ProteinsNF-kappa BTANK protein, humanTLR3 protein, humanToll-Like Receptor 3UBAC1 protein, humanUbiquitin-Protein LigasesBCL10CARD14CARMA2shNF-κBpsoriasisTANKUBAC1Ubiquitin

Identifiers

PMID33316896
PMCPMC7764236
OpenAlexW3110669839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.