ArticleNeuroImage. Clinical2021
Eye gaze patterns and functional brain responses during emotional face processing in adolescents with conduct disorder.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Meta-analytical transdiagnostic neural correlates in common pediatric psychiatric disorders.Scientific reports · 2022Pooled it
- Callous-Unemotional Traits and Their Association with Neurodevelopmental Disorders: Insights from Gaze Behaviour During Emotion Recognition.Children (Basel, Switzerland) · 2026Review
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Impaired Social Attention and Cognitive Empathy in a Paediatric Sample of Children with Symptoms of Anxiety.Research on child and adolescent psychopathology · 2024Article
- Anxiety as a differentiating variable in emotional recognition in juvenile offenders with high callous-unemotional traits.Criminal behaviour and mental health : CBMH · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConduct disorder (CD) is characterized by severe aggressive and antisocial behavior. Initial evidence suggests neural deficits and aberrant eye gaze pattern during emotion processing in CD; both concepts, however, have not yet been studied simultaneously. The present study assessed the functional brain correlates of emotional face processing with and without consideration of concurrent eye gaze behavior in adolescents with CD compared to typically developing (TD) adolescents.
methods58 adolescents (23CD/35TD; average age = 16 years/range = 14-19 years) underwent an implicit emotional face processing task. Neuroimaging analyses were conducted for a priori-defined regions of interest (insula, amygdala, and medial orbitofrontal cortex) and using a full-factorial design assessing the main effects of emotion (neutral, anger, fear), group and the interaction thereof (cluster-level, p < .05 FWE-corrected) with and without consideration of concurrent eye gaze behavior (i.e., time spent on the eye region).
resultsAdolescents with CD showed significant hypo-activations during emotional face processing in right anterior insula compared to TD adolescents, independent of the emotion presented. In-scanner eye-tracking data revealed that adolescents with CD spent significantly less time on the eye, but not mouth region. Correcting for eye gaze behavior during emotional face processing reduced group differences previously observed for right insula.
conclusionsAtypical insula activation during emotional face processing in adolescents with CD may partly be explained by attentional mechanisms (i.e., reduced gaze allocation to the eyes, independent of the emotion presented). An increased understanding of the mechanism causal for emotion processing deficits observed in CD may ultimately aid the development of personalized intervention programs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.