Evidence map›Paper›PMID 33316603›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2021

Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity.

Virginia E Sturm, Ashlin R K Roy, Samir Datta, Cheng Wang, Isabel J Sible, Sarah R Holley, Christa Watson, Eleanor R Palser, Nathaniel A Morris, Giovanni Battistella and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Structural neuroanatomy of human facial behaviors.Social cognitive and affective neuroscience · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 1 country.

Virginia E SturmDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: virginia.sturm@ucsf.edu.
Ashlin R K RoyDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: ashlin.roy@ucsf.edu.
Samir DattaDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: samir.datta@ucsf.edu.
Cheng WangDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: cwang.neurosci@outlook.com.
Isabel J SibleDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: ijsible@gmail.com.
Sarah R HolleyDepartment of Psychology, San Francisco State University, San Francisco, CA, USA. Electronic address: sholley@sfsu.edu.
Christa WatsonDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: christa.watson@ucsf.edu.
Eleanor R PalserDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: eleanor.palser@ucsf.edu.
Nathaniel A MorrisDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: nathaniel.morris@ucsf.edu.
Giovanni BattistellaDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: giovanni.battistella@ucsf.edu.
Esther RahDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: estherrah30@gmail.com.
Marita MeyerDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: meyerm77@gmail.com.
Mikhail PakvasaDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: mkpakvasa@gmail.com.
Maria Luisa MandelliDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: marialuisa.mandelli@ucsf.edu.
Jessica DeleonDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: jessica.deleon@ucsf.edu.
Fumiko HoeftDepartment of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: fumiko.hoeft@ucsf.edu.
Eduardo CaverzasiDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: eduardo.caverzasi@ucsf.edu.
Zachary A MillerDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: zachary.miller2@ucsf.edu.
Kevin A ShapiroDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: kevin.shapiro@gmail.com.
Robert HendrenDepartment of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: robert.hendren@ucsf.edu.
Bruce L MillerDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA. Electronic address: bruce.miller@ucsf.edu.
Maria Luisa Gorno-TempiniDepartment of Neurology, University of California, UCSF Memory and Aging Center, Sandler Neurosciences Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: marialuisa.gornotempini@ucsf.edu.
University Memory and Aging Center · USUniversity of California, San Francisco · USSan Francisco State University · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS P01 AG019724NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Dyslexia is a neurodevelopmental disorder mainly defined by reading difficulties. During reading, individuals with dyslexia exhibit hypoactivity in left-lateralized language systems. Lower activity in one brain circuit can be accompanied by greater activity in another, and, here, we examined whether right-hemisphere-based emotional reactivity may be elevated in dyslexia. We measured emotional reactivity (i.e., facial behavior, physiological activity, and subjective experience) in 54 children ages 7-12 with (n = 32) and without (n = 22) dyslexia while they viewed emotion-inducing film clips. Participants also underwent task-free functional magnetic resonance imaging. Parents of children with dyslexia completed the Behavior Assessment System for Children, which assesses real-world behavior. During film viewing, children with dyslexia exhibited significantly greater reactivity in emotional facial behavior, skin conductance level, and respiration rate than those without dyslexia. Across the sample, greater emotional facial behavior correlated with stronger connectivity between right ventral anterior insula and right pregenual anterior cingulate cortex (p

Indexed as

DyslexiaBrain MappingChildEmotionsHumansLanguageMagnetic Resonance ImagingReadingAutonomic nervous systemDevelopmentEmotion generationLateralityReading

Identifiers

PMID33316603
PMCPMC7880083
OpenAlexW3101709485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.