Evidence map›Paper›PMID 33316435›Full record

Trial reportAnnals of physical and rehabilitation medicine2021

A randomized trial of aerobic exercise in chronic kidney disease: Evidence for blunted cardiopulmonary adaptations.

Danielle L Kirkman, Meghan G Ramick, Bryce J Muth, Joseph M Stock, Raymond R Townsend, David G Edwards

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of physical and rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02050035 (Exercise and Vascular Function in Chronic Kidney Disease), which is not on this map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02050035 phase4completednot on this map

Exercise and Vascular Function in Chronic Kidney Disease

TypeinterventionalSponsorUniversity of DelawareRan2013 to 2017Enrolled76ConditionsChronic Renal InsufficiencyArmsAerobic Exercise Training
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Danielle L KirkmanDepartment of Kinesiology and Applied Physiology, University of Delaware, 201Q Health Sciences Complex, 540 S. College Ave, Newark, DE, 19716, USA; Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: dlkirkman@vcu.edu.
Meghan G RamickDepartment of Kinesiology and Applied Physiology, University of Delaware, 201Q Health Sciences Complex, 540 S. College Ave, Newark, DE, 19716, USA; Department of Kinesiology, West Chester University, West Chester, PA, USA. Electronic address: mramick@wcupa.edu.
Bryce J MuthDepartment of Kinesiology and Applied Physiology, University of Delaware, 201Q Health Sciences Complex, 540 S. College Ave, Newark, DE, 19716, USA; School of Health Sciences, Stockton University, Galloway, NJ, USA. Electronic address: bryce.muth@stockton.edu.
Joseph M StockDepartment of Kinesiology and Applied Physiology, University of Delaware, 201Q Health Sciences Complex, 540 S. College Ave, Newark, DE, 19716, USA. Electronic address: jmstock@udel.edu.
Raymond R TownsendPerelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. Electronic address: townsend@upenn.edu.
David G EdwardsDepartment of Kinesiology and Applied Physiology, University of Delaware, 201Q Health Sciences Complex, 540 S. College Ave, Newark, DE, 19716, USA. Electronic address: dge@udel.edu.
University of Delaware · USStockton University · USUniversity of Pennsylvania · USVirginia Commonwealth University · USWest Chester University · US

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI LENNON, SHANNON L. · 2016 to 2025
$23.3M
Exercise and Vascular Function in Chronic Kidney DiseaseR01HL113514 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G · 2013 to 2015
$1.2M
NHLBI NIH HHS R01 HL113514NIGMS NIH HHS P20 GM113125
6 · The paper itself

Abstract

backgroundPatients with chronic kidney disease have reduced cardiorespiratory fitness levels that contribute to mortality.

objectivesThe purpose of this study was to investigate the effects of aerobic exercise on cardiopulmonary function in patients with chronic kidney disease.

methodsA total of 36 patients (mean [SD] estimated glomerular filtration rate 44 [12] ml/min/1.73m

resultsExercise training improved VO

conclusionsCardiopulmonary adaptations appeared to be attenuated in patients with chronic kidney disease and were not fully restored to levels observed in healthy individuals. Improvements in exercise capacity did not confer benefits to physical function. Interventions coupled with exercise may be required to enhance adaptations in chronic kidney disease. Performed according to CONSORT guidelines; ClinicalTrials.gov: NCT02050035.

Indexed as

Cardiorespiratory FitnessRenal Insufficiency, ChronicExerciseHealth StatusHumansCardiorespiratory fitnessChronicExercisePhysical function performanceRenal insufficiency

Identifiers

PMID33316435
PMCPMC8943710
OpenAlexW3117051518

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.